Tubocurarine: Difference between revisions
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==Overview== | ==Overview== | ||
'''Tubocurarine chloride''' is a mixed [[antagonist]] of nicotinic neuromuscular acetylcholine receptors, used to paralyse patients undergoing [[anaesthesia]]. It is one of the chemicals that can be obtained from [[curare]], itself an extract of ''Chondrodendron tomentosum'', a plant found in South American jungles which is used as a source of arrow poison. Native indians hunting animals with this poison were able to eat the animal's contaminated flesh without being affected by the toxin because tubocurarine cannot easily cross [[mucous membranes]] and is thus inactive orally. | '''Tubocurarine chloride''' is a mixed [[antagonist]] of nicotinic neuromuscular acetylcholine receptors, used to paralyse patients undergoing [[anaesthesia]]. It is one of the chemicals that can be obtained from [[curare]], itself an extract of ''Chondrodendron tomentosum'', a plant found in South American jungles which is used as a source of arrow poison. Native indians hunting animals with this poison were able to eat the animal's contaminated flesh without being affected by the toxin because tubocurarine cannot easily cross [[mucous membranes]] and is thus inactive orally. | ||
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[[Category:Alkaloids]] | [[Category:Alkaloids]] | ||
[[Category:Quaternary ammonium compounds]] | [[Category:Quaternary ammonium compounds]] | ||
[[de:Tubocurarin]] | [[de:Tubocurarin]] | ||
[[fr:Tubocurarine]] | [[fr:Tubocurarine]] | ||
Revision as of 17:08, 20 August 2012
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| Routes of administration | I.V. |
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| Pharmacokinetic data | |
| Protein binding | 50% |
| Elimination half-life | 1-2 Hours |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C37H41N2O6 |
| Molar mass | 609.731 g/mol |
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Most recent articles on Tubocurarine Most cited articles on Tubocurarine |
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Powerpoint slides on Tubocurarine |
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Evidence Based Medicine |
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Ongoing Trials on Tubocurarine at Clinical Trials.gov Clinical Trials on Tubocurarine at Google
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US National Guidelines Clearinghouse on Tubocurarine
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Patient resources on Tubocurarine Discussion groups on Tubocurarine Patient Handouts on Tubocurarine Directions to Hospitals Treating Tubocurarine Risk calculators and risk factors for Tubocurarine
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Causes & Risk Factors for Tubocurarine |
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Overview
Tubocurarine chloride is a mixed antagonist of nicotinic neuromuscular acetylcholine receptors, used to paralyse patients undergoing anaesthesia. It is one of the chemicals that can be obtained from curare, itself an extract of Chondrodendron tomentosum, a plant found in South American jungles which is used as a source of arrow poison. Native indians hunting animals with this poison were able to eat the animal's contaminated flesh without being affected by the toxin because tubocurarine cannot easily cross mucous membranes and is thus inactive orally.
Medically, first used in 1912. Introduced in anaesthesia in 1942. The correct chemical structure was only elucidated circa 1970, even though the plant had been known since the Spanish Conquest.
The word curare comes from the South American Indian name for the arrow poison: "ourare". Presumably the initial syllable was pronounced with a heavy glottal stroke. Tubocurarine is so called because the plant samples containing it were first shipped to Europe in tubes.
Today, tubocurarine has fallen into disuse in western medicine, as safer synthetic alternatives such as atracurium are available. However, tubocurarine is still used in the United States and elsewhere as part of the lethal injection procedure.
Other names
d-Tubocurarine. Tubocurarin. Tubocurarinum. Delacurarine. Tubarine. Metubine. Jex
HSDB 2152. Isoquinoline Alkaloid. Tubadil. Mecostrin. Intracostin. Intocostrin.
- Pages with script errors
- Drugs with non-standard legal status
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
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- Articles containing unverified chemical infoboxes
- Muscle relaxants
- Alkaloids
- Quaternary ammonium compounds