B-cell prolymphocytic leukemia: Difference between revisions
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==Overview== | |||
'''B-cell prolymphocytic leukemia''' is a more aggressive, but still treatable, form of [[chronic lymphocytic leukemia]]. The malignant [[B cells]] are larger than average. The name is commonly abbreviated B-PLL. | '''B-cell prolymphocytic leukemia''' is a more aggressive, but still treatable, form of [[chronic lymphocytic leukemia]]. The malignant [[B cells]] are larger than average. The name is commonly abbreviated B-PLL. | ||
Revision as of 15:42, 12 June 2009
| B-cell prolymphocytic leukemia | |
| ICD-O: | 9833 |
|---|---|
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of chronic lymphocytic leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.
It can involve deletions from chromosome 11 and chromosome 13.[1]
It has a relatively poor prognosis.[2]
References
- ↑ Lens D, Matutes E, Catovsky D, Coignet LJ (2000). "Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL)". Leukemia. 14 (3): 427–30. PMID 10720137.
- ↑ Del Giudice I, Davis Z, Matutes E; et al. (2006). "IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)". Leukemia. 20 (7): 1231–7. doi:10.1038/sj.leu.2404238. PMID 16642047.