Granulosa cell tumour: Difference between revisions
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Revision as of 21:56, 28 July 2011
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Overview
Granulosa cell tumours (or granulosa-theca) are part of the sex cord-stromal tumour group of ovarian neoplasms.
The peak age at which they occur is 50-55 years, but they may occur at any age.
Clinical presentation
Estrogens are produced by functioning tumours, and the clinical presentation depends on the patient's age.
- If the patient is postmenopausal, she usually presents with abnormal uterine bleeding.
- If the patient is of reproductive age, she would present with menometrorrhagia.
- If the patient has not undergone puberty, isosexual-pseudo-precocity may be seen.
Histology
The most characteristic gross appearance is a smooth surfaced solid and cystic lesion with the cysts filled with blood. Hemoperitoneum is an infrequent but classical presentation. A large variety of histological presentations exists, but they have two key features:
- Call-Exner bodies (granulosa cells arranged haphazardly around a space containing eosinophilic fluid); and
- Pale uniform nuclei, often with grooves