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   ICD9          = {{ICD9|176}} |
   ICD9          = {{ICD9|176}} |
   ICDO          = {{ICDO|9140|3}} |
   ICDO          = {{ICDO|9140|3}} |
  Image          = Kaposi’s sarcoma intraoral AIDS 072 lores.jpg |
  Caption        = <center>Intraoral Kaposi’s sarcoma lesion with an overlying [[candidiasis]] infection.</center>|
   OMIM          = 148000 |
   OMIM          = 148000 |
   MedlinePlus    = 000661 |
   MedlinePlus    = 000661 |
  eMedicineSubj  = med |
  eMedicineTopic = 1218 |
  eMedicine_mult = {{eMedicine2|derm|203}} {{eMedicine2|oph|481}} |
   DiseasesDB    = 7105 |
   DiseasesDB    = 7105 |
}}
}}
{{SI}}
{{SI}}


{{CMG}}; Jinhui Wu, MD
'''Editor-in-Chief:''' [[C. Michael Gibson]], M.S.,M.D. [mailto:mgibson@perfuse.org]  Phone:617-632-7753; '''Associate Editor-In-Chief:''' Jinhui Wu, M.D.
 
{{EJ}}


==What is Kaposi's sarcoma?==
==Overview==
Kaposi sarcoma (KS) is a cancer caused by the Kaposi sarcoma herpesvirus (KSHV). Someone who is infected with KSHV is more likely to develop Kaposi sarcoma if he is infection with the human immunodeficiency virus (HIV). Usual symptoms may be lesions on the surface of skin, or painful swelling in the legs, groin area, or skin around the eyes. Besides, Kaposi's sarcoma can cause serious problems such as bleeding and difficulty breathing when the lesions are in internal organs. Treatments include local therapy, [[radiation therapy]], [[chemotherapy]] and biologic therapy.
Kaposi sarcoma (KS) is a cancer caused by the Kaposi sarcoma herpesvirus (KSHV). Someone who is infected with KSHV is more likely to develop Kaposi sarcoma if he is infection with the human immunodeficiency virus (HIV). Usual symptoms may be lesions on the surface of skin, or painful swelling in the legs, groin area, or skin around the eyes. Besides, Kaposi's sarcoma can cause serious problems such as bleeding and difficulty breathing when the lesions are in internal organs. Treatments include local therapy, [[radiation therapy]], [[chemotherapy]] and biologic therapy.


==How do I know if I have Kaposi's sarcoma and what are the symptoms of Kaposi's sarcoma?==
==What are the symptoms of Kaposi's sarcoma?==
Usual symptoms include skin and internal organs.
Usual symptoms include skin and internal organs.


:*Lesions in skin: The lesions can develop anywhere on the body, but most often on the legs, nose, the feet. Typical lesions begin as flat or slightly raised pink or red spots. With the developement of the disease, the colour of the lesions may be change into blue, purple, or brown.  
*'''Lesions in skin:''' The lesions can develop anywhere on the body, but most often on the legs, nose, the feet. Typical lesions begin as flat or slightly raised pink or red spots. With the developement of the disease, the colour of the lesions may be change into blue, purple, or brown.  


:*Lesions in mouth and throat: The disease may cause sore, ooze, bleed, or swallow and breath problems in mouth and throat.
*'''Lesions in mouth and throat:''' The disease may cause sore, ooze, bleed, or swallow and breath problems in mouth and throat.


:*Lesions in gastrointestinal tract: The sarcoma may cause bleeding, anemia, abdominal pain and discomfort, even bowel obstruction.
*'''Lesions in gastrointestinal tract:''' The sarcoma may cause bleeding, anemia, abdominal pain and discomfort, even bowel obstruction.


:*Lesions in lung: When Kaposi's sarcoma in lung, it can make coughing, bloody sputum, shortness of breath, and fever.  
*'''Lesions in lung:''' When Kaposi's sarcoma in lung, it can make coughing, bloody sputum, shortness of breath, and fever.  


Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible.
Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible.
Line 41: Line 33:
Clinical data has suggested that the development of kidney cancer is related to several factors.  
Clinical data has suggested that the development of kidney cancer is related to several factors.  


:*Infection with Kaposi sarcoma herpesvirus (KSHV): Kaposi's sarcoma only develops in people who are infected with KSHV.  
*Infection with Kaposi sarcoma herpesvirus (KSHV): Kaposi's sarcoma only develops in people who are infected with KSHV.  


:*Immune deficiency: A defect in the immune system increases the chance to developing Kaposi's sarcoma, especially when people with AIDS.
*Immune deficiency: A defect in the immune system increases the chance to developing Kaposi's sarcoma, especially when people with AIDS.


:*Race: Epidemiological data show that people in Eastern European, Mediterranean, and Middle Eastern descent have a higher rate of getting Kaposi's sarcoma.
*Race: Epidemiological data show that people in Eastern European, Mediterranean, and Middle Eastern descent have a higher rate of getting Kaposi's sarcoma.


:*Gender: Men are much more likely to get Kaposi's sarcoma than women in many places. But in Africa, men, women and children are all at risk of Kaposi's sarcoma
*Gender: Men are much more likely to get Kaposi's sarcoma than women in many places. But in Africa, men, women and children are all at risk of Kaposi's sarcoma


:*Sexual activity: Scientists have found faggotry are more likely to get Kaposi's sarcoma than Lesbian.
*Sexual activity: Scientists have found faggotry are more likely to get Kaposi's sarcoma than Lesbian.


==How to know you have Kaposi's sarcoma?==
==How to know you have Kaposi's sarcoma?==
:*[[Biopsy]]: For the skin lesions, biopsy is the best way to detect whether the lesion is Kaposi's sarcoma or not. In this procedure, the doctor usually performs a punch biopsy and removes a tiny round piece of tissue. Then, the pathologists can detect the tissues under the microcope.
*'''[[Biopsy]]:''' For the skin lesions, biopsy is the best way to detect whether the lesion is Kaposi's sarcoma or not. In this procedure, the doctor usually performs a punch biopsy and removes a tiny round piece of tissue. Then, the pathologists can detect the tissues under the microcope.


:*Computed tomography (CT) scan: CT scans are often used to show abnormal in the lung. It can confirm the location of the cancer and show the organs near the lung as well as lymph nodes.  
*'''Computed tomography (CT) scan:''' CT scans are often used to show abnormal in the lung. It can confirm the location of the cancer and show the organs near the lung as well as lymph nodes.  


:*Bronchoscopy and biopsy: This is the way to remove the abnormal tissues in the lung and to detect whether it is Kaposi's sarcoma or not by the pathologist.
*'''Bronchoscopy and biopsy:''' This is the way to remove the abnormal tissues in the lung and to detect whether it is Kaposi's sarcoma or not by the pathologist.


:*Gastrointestinal endoscopy and biopsy: This is the way to remove the abnormal tissues in the gastrointestinal tract and transfer to the pathologist to detect whether it is Kaposi's sarcoma or not.
*'''Gastrointestinal endoscopy and biopsy:''' This is the way to remove the abnormal tissues in the gastrointestinal tract and transfer to the pathologist to detect whether it is Kaposi's sarcoma or not.


==When to seek urgent medical care?==
==When to seek urgent medical care?==
Kaposi's sarcoma in internal organs is a tumor that cannot be found early. If symptoms of Kaposi's sarcoma develop, go to see your doctor as soon as possible:
Kaposi's sarcoma in internal organs is a tumor that cannot be found early. If symptoms of Kaposi's sarcoma develop, go to see your doctor as soon as possible:


:*Severe gastrointestinal tract [[bleeding]]
*Severe gastrointestinal tract [[bleeding]]
:*Severe breath prolem
*Severe breath prolem


==Treatment options==
==Treatment options==
Patients with Kaposi's sarcoma have many treatment options. The selection depends on the stage of the tumor. The options are local therapy, radiation therapy, chemotherapy, biologic drugs treatment, or a combination of these methods. Before treatment starts, ask your health care team about possible side effects and how treatment may change your normal activities. Because cancer treatments often damage healthy cells and tissues, side effects are common. [[Side effect]] may not be the same for each person, and they may change from one treatment session to the next.
Patients with Kaposi's sarcoma have many treatment options. The selection depends on the stage of the tumor. The options are local therapy, radiation therapy, chemotherapy, biologic drugs treatment, or a combination of these methods. Before treatment starts, ask your health care team about possible side effects and how treatment may change your normal activities. Because cancer treatments often damage healthy cells and tissues, side effects are common. [[Side effect]] may not be the same for each person, and they may change from one treatment session to the next.


'''Local therapy'''
*'''Local therapy'''


:*Topical treatment: This is the treatment to put medicine directly on the lesions.
:*Topical treatment: This is the treatment to put medicine directly on the lesions.
Line 75: Line 67:
:*Intralesional chemotherapy: In this procedure, the chemotherapy drug is injected directly into the Kaposi's sarcoma lesions.
:*Intralesional chemotherapy: In this procedure, the chemotherapy drug is injected directly into the Kaposi's sarcoma lesions.


'''Radiation therapy:''' This is a cancer treatment to kill cancer cells or keep them from growing by using high-energy x-rays or other types of radiation.
*'''Radiation therapy:''' This is a cancer treatment to kill cancer cells or keep them from growing by using high-energy x-rays or other types of radiation.


'''Chemotherapy:''' The treatment is to use drugs to stop the growth of cancer cells either by killing the cells or by stopping them from dividing
*'''Chemotherapy:''' The treatment is to use drugs to stop the growth of cancer cells either by killing the cells or by stopping them from dividing


'''Biologic therapy:''' This treatment uses chemicals such as interferon alpha to help the immune system attack cancer cells.
*'''Biologic therapy:''' This treatment uses chemicals such as interferon alpha to help the immune system attack cancer cells.


==Diseases with similar symptoms==
==Diseases with similar symptoms==
'''Lesions in skin'''
*'''Lesions in skin'''


:*[[Skin cancer]]
:*[[Skin cancer]]
Line 88: Line 80:
:*[[Erythematous lupus]]
:*[[Erythematous lupus]]


'''Leisons in lung'''
*'''Leisons in lung'''


:*[[Lung cancer]]
:*[[Lung cancer]]
:*[[Metastatic lung cancer]]
:*[[Metastatic lung cancer]]


'''Lesions in gastrointestinal tract'''
*'''Lesions in gastrointestinal tract'''


:*[[Peptic ulcer]]
:*[[Peptic ulcer]]
Line 103: Line 95:


==Prevention of Kaposi's sarcoma==
==Prevention of Kaposi's sarcoma==
'''Avoiding the infection of HIV'''
*'''Avoiding the infection of HIV:'''


:*Avoiding unprotected sex with people infected with HIV  
:*Avoiding unprotected sex with people infected with HIV  
Line 109: Line 101:
:*Do not use contaminated needles to inject recreational drugs
:*Do not use contaminated needles to inject recreational drugs


'''For people infected with HIV, reducing the chance to develope Kaposi's sarcoma'''  
*'''For people infected with HIV, reducing the chance to develope Kaposi's sarcoma:'''  


:*Highly active antiretroviral therapy (HAART)
:*Highly active antiretroviral therapy (HAART)
Line 117: Line 109:
The prognosis of Kaposi's sarcoma depends on the following:
The prognosis of Kaposi's sarcoma depends on the following:


:*The type of Kaposi sarcoma
*The type of Kaposi sarcoma
:*Whether the cancer has spread
*Whether the cancer has spread
:*Whether the cancer has just been diagnosed or has recurred
*Whether the cancer has just been diagnosed or has recurred
:*The patient's general health, especially the immune system.
*The patient's general health, especially the immune system.


==Copyleft Sources==
==Sources==
http://www.cancer.gov/cancertopics/pdq/treatment/kaposis/patient
http://www.cancer.gov/cancertopics/pdq/treatment/kaposis/patient


http://www.cancer.org/docroot/cri/content/cri_2_4_1x_what_is_kaposis_sarcoma_21.asp?sitearea=cri
http://www.cancer.org/docroot/cri/content/cri_2_4_1x_what_is_kaposis_sarcoma_21.asp?sitearea=cri
{{SIB}}
[[Category:Disease state]]
[[Category:HIV/AIDS]]
[[Category:Oncology]]
[[Category:Dermatology]]
[[Category:Pulmonology]]
[[Category:Gastroenterology]]
[[Category:Infectious disease]]
[[Category:Patient information]]
[[Category:HIV/AIDS patient information]]
[[Category:Infectious disease patient information]]
[[Category:Oncology patient information]]
[[Category:Dermatology patient information]]
[[Category:Pulmonology patient information]]
[[Category:Gastroenterology patient information]]
[[Category:Mature chapter]]


{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Patient Information]]

Revision as of 23:35, 28 July 2011

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Editor-in-Chief: C. Michael Gibson, M.S.,M.D. [1] Phone:617-632-7753; Associate Editor-In-Chief: Jinhui Wu, M.D.

Overview

Kaposi sarcoma (KS) is a cancer caused by the Kaposi sarcoma herpesvirus (KSHV). Someone who is infected with KSHV is more likely to develop Kaposi sarcoma if he is infection with the human immunodeficiency virus (HIV). Usual symptoms may be lesions on the surface of skin, or painful swelling in the legs, groin area, or skin around the eyes. Besides, Kaposi's sarcoma can cause serious problems such as bleeding and difficulty breathing when the lesions are in internal organs. Treatments include local therapy, radiation therapy, chemotherapy and biologic therapy.

What are the symptoms of Kaposi's sarcoma?

Usual symptoms include skin and internal organs.

  • Lesions in skin: The lesions can develop anywhere on the body, but most often on the legs, nose, the feet. Typical lesions begin as flat or slightly raised pink or red spots. With the developement of the disease, the colour of the lesions may be change into blue, purple, or brown.
  • Lesions in mouth and throat: The disease may cause sore, ooze, bleed, or swallow and breath problems in mouth and throat.
  • Lesions in gastrointestinal tract: The sarcoma may cause bleeding, anemia, abdominal pain and discomfort, even bowel obstruction.
  • Lesions in lung: When Kaposi's sarcoma in lung, it can make coughing, bloody sputum, shortness of breath, and fever.

Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible.

Who is at risk for Kaposi's sarcoma?

Clinical data has suggested that the development of kidney cancer is related to several factors.

  • Infection with Kaposi sarcoma herpesvirus (KSHV): Kaposi's sarcoma only develops in people who are infected with KSHV.
  • Immune deficiency: A defect in the immune system increases the chance to developing Kaposi's sarcoma, especially when people with AIDS.
  • Race: Epidemiological data show that people in Eastern European, Mediterranean, and Middle Eastern descent have a higher rate of getting Kaposi's sarcoma.
  • Gender: Men are much more likely to get Kaposi's sarcoma than women in many places. But in Africa, men, women and children are all at risk of Kaposi's sarcoma
  • Sexual activity: Scientists have found faggotry are more likely to get Kaposi's sarcoma than Lesbian.

How to know you have Kaposi's sarcoma?

  • Biopsy: For the skin lesions, biopsy is the best way to detect whether the lesion is Kaposi's sarcoma or not. In this procedure, the doctor usually performs a punch biopsy and removes a tiny round piece of tissue. Then, the pathologists can detect the tissues under the microcope.
  • Computed tomography (CT) scan: CT scans are often used to show abnormal in the lung. It can confirm the location of the cancer and show the organs near the lung as well as lymph nodes.
  • Bronchoscopy and biopsy: This is the way to remove the abnormal tissues in the lung and to detect whether it is Kaposi's sarcoma or not by the pathologist.
  • Gastrointestinal endoscopy and biopsy: This is the way to remove the abnormal tissues in the gastrointestinal tract and transfer to the pathologist to detect whether it is Kaposi's sarcoma or not.

When to seek urgent medical care?

Kaposi's sarcoma in internal organs is a tumor that cannot be found early. If symptoms of Kaposi's sarcoma develop, go to see your doctor as soon as possible:

  • Severe gastrointestinal tract bleeding
  • Severe breath prolem

Treatment options

Patients with Kaposi's sarcoma have many treatment options. The selection depends on the stage of the tumor. The options are local therapy, radiation therapy, chemotherapy, biologic drugs treatment, or a combination of these methods. Before treatment starts, ask your health care team about possible side effects and how treatment may change your normal activities. Because cancer treatments often damage healthy cells and tissues, side effects are common. Side effect may not be the same for each person, and they may change from one treatment session to the next.

  • Local therapy
  • Topical treatment: This is the treatment to put medicine directly on the lesions.
  • Cryosurgery: During this procedure, the doctor use a probe cooled with liquid nitrogen to freeze the lesions.
  • Intralesional chemotherapy: In this procedure, the chemotherapy drug is injected directly into the Kaposi's sarcoma lesions.
  • Radiation therapy: This is a cancer treatment to kill cancer cells or keep them from growing by using high-energy x-rays or other types of radiation.
  • Chemotherapy: The treatment is to use drugs to stop the growth of cancer cells either by killing the cells or by stopping them from dividing
  • Biologic therapy: This treatment uses chemicals such as interferon alpha to help the immune system attack cancer cells.

Diseases with similar symptoms

  • Lesions in skin
  • Leisons in lung
  • Lesions in gastrointestinal tract

Where to find medical care for Kaposi's sarcoma?

Directions to Hospitals Treating Kaposi's sarcoma

Prevention of Kaposi's sarcoma

  • Avoiding the infection of HIV:
  • Avoiding unprotected sex with people infected with HIV
  • Using a condom during any sexual contact
  • Do not use contaminated needles to inject recreational drugs
  • For people infected with HIV, reducing the chance to develope Kaposi's sarcoma:
  • Highly active antiretroviral therapy (HAART)
  • Taking drugs such as ganciclovir or foscarnet to block herpesvirus

What to expect (Outook/Prognosis)?

The prognosis of Kaposi's sarcoma depends on the following:

  • The type of Kaposi sarcoma
  • Whether the cancer has spread
  • Whether the cancer has just been diagnosed or has recurred
  • The patient's general health, especially the immune system.

Sources

http://www.cancer.gov/cancertopics/pdq/treatment/kaposis/patient

http://www.cancer.org/docroot/cri/content/cri_2_4_1x_what_is_kaposis_sarcoma_21.asp?sitearea=cri

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