Systemic disease: Difference between revisions
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== Detection == | == Detection == | ||
Getting a regular eye exam may play a role in identifying the signs of some systemic diseases. "The eye is composed of many different types of tissue. This unique feature makes the eye susceptible to a wide variety of diseases as well as provides insights into many body systems. Almost any part of the eye can give important clues to the diagnosis of systemic diseases. Signs of a systemic disease may be evident on the outer surface of the eye (eyelids, conjunctiva and cornea), middle of the eye and at the back of the eye (retina)."<ref>"The Eye in Systemic Disease" (University of Illinois at Chicago: 2008), Available at: http://www.uic.edu/com/eye/LearningAboutVision/EyeFacts/SystemicDisease.shtml, Accessed 08/20/2009.</ref> | Getting a regular [[eye exam]] may play a role in identifying the signs of some [[systemic diseases]]. "The [[eye]] is composed of many different types of [[tissue]]. This unique feature makes the [[eye]] susceptible to a wide variety of [[diseases]] as well as provides insights into many [[body systems]]. Almost any part of the [[eye]] can give important clues to the [[diagnosis]] of [[systemic diseases]]. Signs of a [[systemic disease]] may be evident on the outer surface of the [[eye]] ([[eyelids]], [[conjunctiva]] and [[cornea]]), middle of the [[eye]] and at the back of the [[eye]] ([[retina]])."<ref>"The Eye in Systemic Disease" (University of Illinois at Chicago: 2008), Available at: http://www.uic.edu/com/eye/LearningAboutVision/EyeFacts/SystemicDisease.shtml, Accessed 08/20/2009.</ref> | ||
Since 500 B.C., some researchers have also believed that the physical condition of the fingernails and toenails can indicate various systemic diseases. Careful examination of the fingernails and toenails may provide clues to underlying systemic diseases, since some diseases have been found to cause disruptions in the nail growth process. The [[nail plate]] is the hard [[keratin]] cover of the nail. The nail plate is generated by the [[nail matrix]] located just under the cuticle. As the nail grows, the area closest to becoming exposed to the outside world (distal) produces the deeper layers of the nail plate, while the part of the nail matrix deeper inside the finger (proximal) makes the superficial layers. Any disruption in this growth process can lead to an alteration in the shape and texture. | Since 500 B.C., some researchers have also believed that the physical condition of the [[fingernails]] and [[toenails]] can indicate various [[systemic diseases]]. Careful examination of the [[fingernails]] and [[toenails]] may provide clues to underlying [[systemic diseases]], since some [[diseases]] have been found to cause disruptions in the nail growth process. The [[nail plate]] is the hard [[keratin]] cover of the nail. The [[nail plate]] is generated by the [[nail matrix]] located just under the [[cuticle]]. As the nail grows, the area closest to becoming exposed to the outside world ([[distal]]) produces the deeper layers of the [[nail plate]], while the part of the [[nail matrix]] deeper inside the [[finger]] ([[proximal]]) makes the superficial layers. Any disruption in this growth process can lead to an alteration in the shape and texture. | ||
Take pitting, for example. Pitting looks like depressions in the hard part of the nail. Pitting usually is associated with [[psoriasis]], affecting 10 to 50 percent of patients with that disorder.<ref>Mayeaux EJ Jr. Nail disorders. Prim Care 2000;27: 333-51.</ref> Pitting also may be caused by a variety of systemic diseases, including [[Reiter's syndrome]] and other [[connective tissue disorders]], [[sarcoidosis]], [[pemphigus]], [[alopecia areata]], and [[incontinentia pigmenti]].<ref>Daniel CR 3d, Sams WM Jr, Scher RK. Nails in systemic disease. Dermatol Clin 1985;3:465-83.</ref> Because pitting is caused by defective layering of the superficial nail plate by the proximal nail matrix, any localized dermatitis (e.g., [[atopic|atopic dermatitis]] or chemical [[dermatitis]]) that disrupts orderly growth in that area also can cause pitting.<ref>Eds. ROBERT S. FAWCETT, M.D., M.S., SEAN LINFORD, M.D., and DANIEL L. STULBERG, M.D., ''Nail Abnormalities: Clues to Systemic Disease'' (American Family Physician, March 15, 2004), Available at http://www.aafp.org/afp/20040315/1417.html, Accessed 08/20/2009.</ref> | Take pitting, for example. Pitting looks like depressions in the hard part of the nail. Pitting usually is associated with [[psoriasis]], affecting 10 to 50 percent of patients with that disorder.<ref>Mayeaux EJ Jr. Nail disorders. Prim Care 2000;27: 333-51.</ref> Pitting also may be caused by a variety of [[systemic diseases]], including [[Reiter's syndrome]] and other [[connective tissue disorders]], [[sarcoidosis]], [[pemphigus]], [[alopecia areata]], and [[incontinentia pigmenti]].<ref>Daniel CR 3d, Sams WM Jr, Scher RK. Nails in systemic disease. Dermatol Clin 1985;3:465-83.</ref> Because pitting is caused by defective layering of the superficial [[nail plate]] by the [[proximal]] [[nail matrix]], any localized [[dermatitis]] (e.g., [[atopic|atopic dermatitis]] or chemical [[dermatitis]]) that disrupts orderly growth in that area also can cause pitting.<ref>Eds. ROBERT S. FAWCETT, M.D., M.S., SEAN LINFORD, M.D., and DANIEL L. STULBERG, M.D., ''Nail Abnormalities: Clues to Systemic Disease'' (American Family Physician, March 15, 2004), Available at http://www.aafp.org/afp/20040315/1417.html, Accessed 08/20/2009.</ref> | ||
==See also== | ==See also== | ||
Revision as of 19:54, 4 March 2010
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole [1] Although most medical conditions will eventually involve multiple organs in advanced stage (i.e. Multiple organ dysfunction syndrome), diseases where multiple organ involvement is at presentation or in early stage are considered above.
Examples
- Systemic vasculitis e.g. SLE, PAN
- Sarcoidosis
- Diabetes
- Hypertension
- Metabolic syndrome
- AIDS
Detection
Getting a regular eye exam may play a role in identifying the signs of some systemic diseases. "The eye is composed of many different types of tissue. This unique feature makes the eye susceptible to a wide variety of diseases as well as provides insights into many body systems. Almost any part of the eye can give important clues to the diagnosis of systemic diseases. Signs of a systemic disease may be evident on the outer surface of the eye (eyelids, conjunctiva and cornea), middle of the eye and at the back of the eye (retina)."[2]
Since 500 B.C., some researchers have also believed that the physical condition of the fingernails and toenails can indicate various systemic diseases. Careful examination of the fingernails and toenails may provide clues to underlying systemic diseases, since some diseases have been found to cause disruptions in the nail growth process. The nail plate is the hard keratin cover of the nail. The nail plate is generated by the nail matrix located just under the cuticle. As the nail grows, the area closest to becoming exposed to the outside world (distal) produces the deeper layers of the nail plate, while the part of the nail matrix deeper inside the finger (proximal) makes the superficial layers. Any disruption in this growth process can lead to an alteration in the shape and texture.
Take pitting, for example. Pitting looks like depressions in the hard part of the nail. Pitting usually is associated with psoriasis, affecting 10 to 50 percent of patients with that disorder.[3] Pitting also may be caused by a variety of systemic diseases, including Reiter's syndrome and other connective tissue disorders, sarcoidosis, pemphigus, alopecia areata, and incontinentia pigmenti.[4] Because pitting is caused by defective layering of the superficial nail plate by the proximal nail matrix, any localized dermatitis (e.g., atopic dermatitis or chemical dermatitis) that disrupts orderly growth in that area also can cause pitting.[5]
See also
List of Major Online Medical Dictionaries
References
- ↑ Dorland's Illustrated Medical Dictionary,28th edition (Harcourt Brace & Company). Page 489,1653
- ↑ "The Eye in Systemic Disease" (University of Illinois at Chicago: 2008), Available at: http://www.uic.edu/com/eye/LearningAboutVision/EyeFacts/SystemicDisease.shtml, Accessed 08/20/2009.
- ↑ Mayeaux EJ Jr. Nail disorders. Prim Care 2000;27: 333-51.
- ↑ Daniel CR 3d, Sams WM Jr, Scher RK. Nails in systemic disease. Dermatol Clin 1985;3:465-83.
- ↑ Eds. ROBERT S. FAWCETT, M.D., M.S., SEAN LINFORD, M.D., and DANIEL L. STULBERG, M.D., Nail Abnormalities: Clues to Systemic Disease (American Family Physician, March 15, 2004), Available at http://www.aafp.org/afp/20040315/1417.html, Accessed 08/20/2009.