PCI in the patient with in stent restenosis: Difference between revisions
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In-stent restenosis (ISR) is the most frequent late complication of [[stent]] implantation. It occurs when there is a reoccurrence of [[stenosis]] around a [[lesion]] that has been treated with a [[stent]]. Although ISR has traditionally occurred in 10-80% of treated [[lesions]], its incidence has been dramatically reduced by the development of [[drug-eluting stents]]. | In-stent restenosis (ISR) is the most frequent late complication of [[stent]] implantation. It occurs when there is a reoccurrence of [[stenosis]] around a [[lesion]] that has been treated with a [[stent]]. Although ISR has traditionally occurred in 10-80% of treated [[lesions]], its incidence has been dramatically reduced by the development of [[drug-eluting stents]]. | ||
Certain factors are known to increase the risk of in-stent [[restenosis]], which can be grouped into those that are related to the patient, the [[lesion]], and the procedure. Patients with [[diabetes mellitus]] and [[chronic kidney disease]] are at an increased risk of ISR. Lesions with a great lesion length, small vessel diameter, total [[plaque]] burden, chronic total [[occlusion]], ostial location, and/or vein graft lesion are more likely to experience in-stent [[restenosis]]. | Certain factors are known to increase the risk of in-stent [[restenosis]], which can be grouped into those that are related to the patient, the [[lesion]], and the procedure. Patients with [[diabetes mellitus]] and [[chronic kidney disease]] are at an increased risk of ISR. Lesions with a great lesion length, small vessel diameter, total [[plaque]] burden, chronic total [[occlusion]], ostial location, and/or vein graft lesion are more likely to experience in-stent [[restenosis]]. Additionally, procedure-related factors that increase the risk of ISR include a residual [[stenosis]] >30%, a residual [[pressure gradient]] >20mmHg, and an increased number, overlap, and length of [[stents]]. | ||
Revision as of 20:40, 11 May 2010
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Background
In-stent restenosis (ISR) is the most frequent late complication of stent implantation. It occurs when there is a reoccurrence of stenosis around a lesion that has been treated with a stent. Although ISR has traditionally occurred in 10-80% of treated lesions, its incidence has been dramatically reduced by the development of drug-eluting stents.
Certain factors are known to increase the risk of in-stent restenosis, which can be grouped into those that are related to the patient, the lesion, and the procedure. Patients with diabetes mellitus and chronic kidney disease are at an increased risk of ISR. Lesions with a great lesion length, small vessel diameter, total plaque burden, chronic total occlusion, ostial location, and/or vein graft lesion are more likely to experience in-stent restenosis. Additionally, procedure-related factors that increase the risk of ISR include a residual stenosis >30%, a residual pressure gradient >20mmHg, and an increased number, overlap, and length of stents.