Factor Xa inhibitor antidote

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Synonyms and keywords: Factor Xa inhibitor antidote, factor Xa inhibitor reversal agent, FXa inhibitor antidote

Direct Factor Xa inhibitors include Rivaroxaban, Betrixaban, Apixaban and Edoxaban. These agents bind directly to a serine residue of Factor Xa and inhibit the ability of Factor Xa to bind to the active site. They work by steric hinderance. They bind reversibly. Thus there is an equilibrium where these inhibitor molecules are binding and falling off of the Factor Xa molecule. Indirect inhibitors like fondaparinux and enoxaperin require antithrombin 3AT3 in addition.