Congenital heart disease causes: Difference between revisions
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===Genetics=== | ===Genetics=== | ||
While many genetic syndromes are associated with a congenital heart defect, the obverse is not true and many cases of congenital heart disease are not associated with a genetic defect. Genetic syndromes that are associated with congenital heart defects include , , and . The genetics of congenital heart disease may vary by defect. Other genetic syndromes associated with congenital heart disease include the following: | |||
* [[Alagille syndrome]] | * [[Alagille syndrome]] | ||
Revision as of 11:32, 28 July 2011
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Congenital heart disease Microchapters |
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Differentiating Congenital heart disease from other Disorders |
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Diagnosis |
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Congenital heart disease causes On the Web |
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Risk calculators and risk factors for Congenital heart disease causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Priyamvada Singh, MBBS [2] Assistant Editor-In-Chief: Kristin Feeney, B.S. [3]
Overview
As is common with many congenital related conditions, there are gaps in knowledge regarding the causation of congenital heart disease. Congenital heart disease is multi-factorial in origin, with genetics and environmental factors both playing a role.
Causes
Current knowledge regarding the causes of congenital heart disease is limited. Most research has been based on small studies(<1,000 patients). Congenital heart disease is multi-factorial in origin, with genetics and environmental factors both playing a role.
Genetics
While many genetic syndromes are associated with a congenital heart defect, the obverse is not true and many cases of congenital heart disease are not associated with a genetic defect. Genetic syndromes that are associated with congenital heart defects include , , and . The genetics of congenital heart disease may vary by defect. Other genetic syndromes associated with congenital heart disease include the following:
- Alagille syndrome
- DiGeorge syndrome (22q11 deletion syndrome)
- Down's Syndrome
- Ellis-van Creveld Syndrome
- Holt-Oram syndrome
- Marfan's Syndrome
- Noonan Syndrome
- Trisomy 13
- Turner's Syndrome
Risk factors during pregnancy:
- Maternal rubella infection has been related to PDA, pulmonic valvular stenosis, and ASD
- Chronic maternal alcohol abuse is associated with increased risk of VSD)
- Maternal lupus erythematous is associated with congenital complete heart block
- Ingestion of thalidomide
- Isotretinonin
- Lithium (tricuspid valve anomalies)
- Alcohol use of the mother
- Chemotherapeutics
- Thalidomide
- Retinoic acid
- Immunosuppressives
- Hypoxia (Lack of oxygen)
- Radiation
- Rubella
Sources
- The ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities [1]
References
- ↑ Epstein AE, DiMarco JP, Ellenbogen KA, Estes NAM III, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO. ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices). Circulation. 2008; 117: 2820–2840. PMID 18483207