Autoimmune hemolytic anemia (patient information)

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Autoimmune hemolytic anemia
ICD-10	D59.0-D59.1
ICD-9	283.0
MedlinePlus	000579
MeSH	D000744

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Editor-in-Chief: C. Michael Gibson, M.S.,M.D. [1] Phone:617-632-7753; Associate Editor-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S.

Synonyms and Keywords: Idiopathic autoimmune hemolytic anemia

Overview

Autoimmune hemolytic anemia is a drop in the number of red blood cells due to increased destruction by the body's defense (immune) system.

What are the symptoms of Autoimmune hemolytic anemia?

• Dark urine
• Fatigue
• Pale color (pallor)
• Rapid heartbeat
• Shortness of breath
• Yellow skin color (jaundice)

What causes Autoimmune hemolytic anemia?

• Autoimmune hemolytic anemia is an acquired disease that occurs when antibodies form against a person's own red blood cells. In the idiopathic form of this disease, the cause is unknown.

• Idiopathic autoimmune hemolytic anemia accounts for one-half of all immune hemolytic anemias.

• There are other types of immune hemolytic anemias in which the cause may result from an underlying disease or medication. The disease may start quickly and be very serious.

Who is at highest risk?

Risk factors are not known.

When to seek urgent medical care?

Call your health care provider if you notice symptoms of anemia.

Diagnosis

• An examination may reveal an enlarged spleen.

• Tests include:

• Direct Coombs test
• Hemoglobin in the urine
• Indirect Coombs' test
• Red blood cell count and serum hemoglobin
• Reticulocyte count
• Serum bilirubin levels
• Serum haptoglobin

Treatment options

• The first therapy tried is usually a steroid medication, such as prednisone.
• If steroid medications do not improve the condition, removal of the spleen (splenectomy) may be considered.

• Therapy to suppress the immune system is usually given if the person does not respond to steroids and splenectomy. Medications such as azathioprine (Imuran), cyclophosphamide (Cytoxan), and rituximab (Rituxan) have been used.

• Blood transfusions are given with caution, because of the potential that blood may not be compatible and may cause further hemolysis.

Where to find medical care for Autoimmune hemolytic anemia?

Directions to Hospitals Treating Autoimmune hemolytic anemia

Prevention

There is no known prevention for autoimmune hemolytic anemia, because the cause is unknown.

What to expect (Outlook/Prognosis)?

• Adults may have long-term disease that keeps returning.
• In children the anemia is usually short-lived.

Possible complications

• Infection (as a complication of treatment)
• Severe anemia

Source

http://www.nlm.nih.gov/medlineplus/ency/article/000579.htm