Binswanger's disease: Difference between revisions
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'''Binswanger's disease or Subcortical Leukoencephalopathy''' is a rare form of [[multi-infarct dementia]] caused by damage to deep [[white matter|white brain matter]]. It is characterized by loss of memory and intellectual function and by changes in mood. | '''Binswanger's disease or Subcortical Leukoencephalopathy''' is a rare form of [[multi-infarct dementia]] caused by damage to deep [[white matter|white brain matter]]. It is characterized by loss of memory and intellectual function and by changes in mood. | ||
== | ==Overview== | ||
Binswanger's disease is one of the [[neurological]] syndromes associated with [[hypertension | Binswanger's disease is one of the [[neurological]] syndromes associated with [[hypertension]]. | ||
A patient with long term severe hypertension develops progressive [[dementia]]. [[Computed axial tomography|CT scans]] of the head | ==Risk Factors== | ||
[[Hypertension]] | |||
==Pathophysiology== | |||
The [[histology|histologic]] findings are diffuse, irregular loss of [[axons]] and [[myelin]] accompanied by widespread [[gliosis]]. Small [[infarct]]s may be seen in the [[frontal lobes]]. The [[pathology|pathologic]] mechanism may be damage caused by severe [[atherosclerosis]]. | |||
A patient with long term severe hypertension develops progressive [[dementia]]. | |||
==Diagnosis== | |||
===CT=== | |||
[[Computed axial tomography|CT scans]] of the head demonstrates a diffuse loss of deep hemispheric [[white matter]]. | |||
==Prognosis== | ==Prognosis== | ||
Revision as of 21:02, 10 July 2012
| Binswanger's disease | |
| ICD-10 | I67.3 |
|---|---|
| ICD-9 | 290.12 |
| DiseasesDB | 1405 |
| MeSH | D015140 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Binswanger's disease or Subcortical Leukoencephalopathy is a rare form of multi-infarct dementia caused by damage to deep white brain matter. It is characterized by loss of memory and intellectual function and by changes in mood.
Overview
Binswanger's disease is one of the neurological syndromes associated with hypertension.
Risk Factors
Pathophysiology
The histologic findings are diffuse, irregular loss of axons and myelin accompanied by widespread gliosis. Small infarcts may be seen in the frontal lobes. The pathologic mechanism may be damage caused by severe atherosclerosis.
A patient with long term severe hypertension develops progressive dementia.
Diagnosis
CT
CT scans of the head demonstrates a diffuse loss of deep hemispheric white matter.
Prognosis
Binswanger's disease has no known treatment, let alone cure, although drugs used to treat high blood pressure, depression, arrhythmia and low blood pressure are used to treat the condition's symptoms.[1]
References
de:Subkortikale arteriosklerotische Enzephalopathie no:Binswangers sykdom fi:Binswangerin tauti