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==Physical examination==
==Physical examination==
The physical findings in an adult with an [[ASD]] include those related directly to:
The physical findings in an adult with an ASD include those related directly to:
*The intracardiac shunt
* The intracardiac shunt
*[[congestive heart failure|Right heart failure]]
* Right heart failure


====Systolic Ejection Murmur====
==Murmurs==
Upon [[auscultation]] of the [[Heart sounds|heart sounds]], there may be an ''ejection systolic murmur'' that is attributed to the pulmonic valve. This is due to the increased flow of blood through the pulmonic valve rather than any structural abnormality of the valve leaflets.
During auscultation of the heart, a clinician may find evidence of abnormal heart sounds produced by a cardiac murmur. Atrial septal defect, being a condition that directly influences the hemodynamics between the right and left ventricle, has multiple types of murmurs associated with this condition.


====Fixed Splitting of S2====
* Systolic murmurs
:* Systolic ejection murmur/midsystolic pulmonary flow - caused by the increased flow of blood through the pulmonic valve rather than any structural abnormality of the valve leaflets.
::* Audible when ausculating over the second intercostal space
::* Only associated with a [[thrill]] when there is a very large left-to-right shunt or the presence of a [[pulmonic stenosis]]
:* Systolic crescendo-descrendo murmur - caused by the rapid flow of blood through the peripheral pulmonary arteries.
::* Audible, over the lung fields
:* Mitral regurgitation murmur - caused by one of two conditions:
::*In ostium primum defects, it is the cleft mitral valve
::*In ostium secundum defects, it is the mitral valve prolapse where the holosystolic murmur of the mitral regurgitation emitting to the axilla is audible


*Diastolic murmurs
:*Mid-diastolic murmur (low-to-medium frequency) - caused by a high flow of blood across the tricuspid valve
::*Not influenced by inspiration
::*Left-to-right shunt greater than a ratio of 2:1
:*Pulmonic regurgitation (low-pitched diastolic) murmur - caused by pulmonary artery dilatation
==Cardiac Sounds==
===Fixed Splitting of S<sub>2</sub>===
<youtube v=5tBk1XuEyuM/>
<youtube v=5tBk1XuEyuM/>
'''In individuals with an atrial septal defect, there is a fixed splitting of S<sub>2</sub>. Fixed splitting occurs as a result of the extra blood return during inspiration equalized by the intraseptal communication between the left and right atrium allowed by the defect.'''


In unaffected individuals, there are respiratory variations in the splitting of the second heart sound (S<sub>2</sub>). During respiratory inspiration, the negative intrathoracic pressure causes increased blood return into the right side of the heart. The increased blood volume in the right ventricle causes the pulmonic valve to stay open longer during ventricular systole. This causes a normal delay in the P<sub>2</sub> component of S<sub>2</sub>. During expiration, the positive intrathoracic pressure causes decreased blood return to the right side of the heart. The reduced volume in the right ventricle allows the pulmonic valve to close earlier at the end of ventricular systole, causing P<sub>2</sub> to occur earlier.


'''In individuals with an ASD, there is a fixed splitting of S<sub>2</sub>. The reason why there is a fixed splitting of the second heart sound is that the extra blood return during inspiration gets equalized between the left and right atrium due to the communication that exists between the atria in individuals with ASD'''
==Common Findings==
 
In symptomatic cases, common findings during a physical examination include:
 
* Underdevelopment, below-average size for age
In unaffected individuals, there are respiratory variations in the splitting of the [[Heart sounds|second heart sound]] (S<sub>2</sub>). During respiratory inspiration, the negative intrathoracic pressure causes increased blood return into the right side of the heart. The increased blood volume in the right ventricle causes the pulmonic valve to stay open longer during ventricular [[systole]]. This causes a normal delay in the P<sub>2</sub> component of S<sub>2</sub>. During expiration, the positive intrathoracic pressure causes decreased blood return to the right side of the heart. The reduced volume in the right ventricle allows the pulmonic valve to close earlier at the end of ventricular systole, causing P<sub>2</sub> to occur earlier.
* Precordial palpation
 
:* Atrial enlargement can cause a precordial bulge that makes [[Harrison's groove]], which are a horizontal line at the lower margin of the thorax where the diaphragm attaches to the ribs, founds along the sixth and seventh costal cartilages.
:* A hyperdynamic impulse in the right ventricle can cause a right ventricular heave where there is an increased diastolic filling and large stroke volume, found along the left sternal board and subxiphoid area.
:* Pulsatile, enlarged pulmonary artery palpation can be felt at the second left intercostal space where a more pronounced pulse may be felt if [[pulmonary hypertension]] is present
* Presence of [[pulmonary hypertension]]
* Extrcardiac features:
:*Deformed carpal bones
:*Deformed thumbs
:*Holt-Oram syndrome
:*Deformed radial bones
* [[Eisenmenger's syndrome]]
* [[Atrial septal defect paradoxical embolization|Paradoxical embolization]]


==References==
==References==
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[[Category:Congenital heart disease]]
[[Category:Congenital heart disease]]
[[Category:Mature chapter]]
[[Category:Mature chapter]]
[[Category:Pediatrics]]


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Revision as of 19:51, 18 August 2011

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, MBBS [[2]]; Cafer Zorkun, M.D., Ph.D. [3]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [[4]]

Overview

Upon physical examination, a patient with an atrial septal defect may present with an ejection systolic murmur caused by the fixed splitting of S2.

Physical examination

The physical findings in an adult with an ASD include those related directly to:

  • The intracardiac shunt
  • Right heart failure

Murmurs

During auscultation of the heart, a clinician may find evidence of abnormal heart sounds produced by a cardiac murmur. Atrial septal defect, being a condition that directly influences the hemodynamics between the right and left ventricle, has multiple types of murmurs associated with this condition.

  • Systolic murmurs
  • Systolic ejection murmur/midsystolic pulmonary flow - caused by the increased flow of blood through the pulmonic valve rather than any structural abnormality of the valve leaflets.
  • Audible when ausculating over the second intercostal space
  • Only associated with a thrill when there is a very large left-to-right shunt or the presence of a pulmonic stenosis
  • Systolic crescendo-descrendo murmur - caused by the rapid flow of blood through the peripheral pulmonary arteries.
  • Audible, over the lung fields
  • Mitral regurgitation murmur - caused by one of two conditions:
  • In ostium primum defects, it is the cleft mitral valve
  • In ostium secundum defects, it is the mitral valve prolapse where the holosystolic murmur of the mitral regurgitation emitting to the axilla is audible
  • Diastolic murmurs
  • Mid-diastolic murmur (low-to-medium frequency) - caused by a high flow of blood across the tricuspid valve
  • Not influenced by inspiration
  • Left-to-right shunt greater than a ratio of 2:1
  • Pulmonic regurgitation (low-pitched diastolic) murmur - caused by pulmonary artery dilatation

Cardiac Sounds

Fixed Splitting of S2

<youtube v=5tBk1XuEyuM/> In individuals with an atrial septal defect, there is a fixed splitting of S2. Fixed splitting occurs as a result of the extra blood return during inspiration equalized by the intraseptal communication between the left and right atrium allowed by the defect.

In unaffected individuals, there are respiratory variations in the splitting of the second heart sound (S2). During respiratory inspiration, the negative intrathoracic pressure causes increased blood return into the right side of the heart. The increased blood volume in the right ventricle causes the pulmonic valve to stay open longer during ventricular systole. This causes a normal delay in the P2 component of S2. During expiration, the positive intrathoracic pressure causes decreased blood return to the right side of the heart. The reduced volume in the right ventricle allows the pulmonic valve to close earlier at the end of ventricular systole, causing P2 to occur earlier.

Common Findings

In symptomatic cases, common findings during a physical examination include:

  • Underdevelopment, below-average size for age
  • Precordial palpation
  • Atrial enlargement can cause a precordial bulge that makes Harrison's groove, which are a horizontal line at the lower margin of the thorax where the diaphragm attaches to the ribs, founds along the sixth and seventh costal cartilages.
  • A hyperdynamic impulse in the right ventricle can cause a right ventricular heave where there is an increased diastolic filling and large stroke volume, found along the left sternal board and subxiphoid area.
  • Pulsatile, enlarged pulmonary artery palpation can be felt at the second left intercostal space where a more pronounced pulse may be felt if pulmonary hypertension is present
  • Deformed carpal bones
  • Deformed thumbs
  • Holt-Oram syndrome
  • Deformed radial bones

References

Template:WH Template:WS