Atrial septal defect causes: Difference between revisions
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* The cause of atrial septal defect is not known. There does appear to be a genetic component to the disease as it often occurs in patients with [[Down syndrome]]. [[Atrial septal defect]]s are often associated with other malformations. There is a well described association with primum or secundum ASDs with [[Down syndrome]]. Other associated lesions include: | * The cause of atrial septal defect is not known. There does appear to be a genetic component to the disease as it often occurs in patients with [[Down syndrome]]. [[Atrial septal defect]]s are often associated with other malformations. There is a well described association with primum or secundum ASDs with [[Down syndrome]]. Other associated lesions include: | ||
**[[ | **[[Pulmonary venous return | Partially anomalous pulmonary venous return]] | ||
**[[Pulmonary valve stenosis]] | **[[Pulmonary valve stenosis]] | ||
**[[Mitral stenosis]] or [[mitral valve prolapse]] | **[[Mitral stenosis]] or [[mitral valve prolapse]] | ||
Revision as of 17:20, 31 August 2011
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Atrial Septal Defect Microchapters | |
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Risk calculators and risk factors for Atrial septal defect causes | |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [[2]]; Cafer Zorkun, M.D., Ph.D. [3]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [[4]]
Overview
As is common with most congenital heart conditions, the exact cause of atrial septal defect is not known. Research suggests a potential link between genetic conditions such as Down syndrome and the development of an atrial septal defect. Other potential causes include exposure to environmental contaminants such as rubella as well as alcohol consumption.
Causes
- The cause of atrial septal defect is not known. There does appear to be a genetic component to the disease as it often occurs in patients with Down syndrome. Atrial septal defects are often associated with other malformations. There is a well described association with primum or secundum ASDs with Down syndrome. Other associated lesions include:
As a parent, if you or a sibling of a child have a congenital heart defect, then you should consider genetic counseling.
- If the mother contracts rubella (german measles) during pregnancy, this can increase the risk of congenital heart disease. In one study, exposure to alcohol during pregnancy doubled the risk of an atrial septal defect[2].
References
- ↑ Benson DW, Sharkey A, Fatkin D, Lang P, Basson CT, McDonough B; et al. (1998). "Reduced penetrance, variable expressivity, and genetic heterogeneity of familial atrial septal defects". Circulation. 97 (20): 2043–8. PMID 9610535.
- ↑ Tikkanen J, Heinonen OP (1992). "Risk factors for atrial septal defect". Eur J Epidemiol. 8 (4): 509–15. PMID 1397217.