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Revision as of 15:32, 21 September 2012

For patient information, click here

Veno-occlusive disease Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Veno-occlusive disease from other Diseases

Epidemiology and Demographics

Risk Factors

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Natural History, Complications and Prognosis

Diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and Keywords: VOD, sinuosoidal obstruction syndrome

Overview

Veno-occlusive disease (VOD) is a disease of the liver in which the veins in the liver are obstructed or blocked. VOD is a complication that occurs in up to 25% of bone marrow transplantations, and may also occur after ingestion of certain plant alkaloids.

Pathophysiology

VOD is also known as sinuosoidal obstruction syndrome due to obstruction of the venous system. Following bone marrow transplantation, VOD has been hypothesized to be due to injury to the hepatic venous endothelium from the conditioning regimen.

Prognosis

When associated with bone marrow transplant, VOD is fatal in over 30% of cases. Cases due to plant alkaloids often have a longer and more unpredictable course.

Diagnosis

Symptoms

Physical Examination

Abdominal Examination

Laboratory Studies

Treatment

Treatment for VOD is primarily supportive. In the BMT setting, defibrotide is an investigational treatment that may be promising. Defibrotide is a polydeoxyribonucleotide; its mechanism of benefit in VOD is unclear, but has been attributed to its antithromboitc properties.

Sources

Kumar, V., Abbas, A. and N. Fausto. 2004. Robbins & Cotran Pathologic Basis of Disease. Philadelphia: W. B. Saunders Company.

References

External link