Pulmonary hypertension causes: Difference between revisions
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==Overview== | |||
Etiologies of Pulmonary Hypertension organized under the Updated Clinical Classification of Pulmonary Hypertension(Dana point,2008) | |||
==Pulmonary Aterial Hypertension== | ==Class 1: Pulmonary Aterial Hypertension== | ||
#Idiopathic PAH | #Idiopathic PAH | ||
#Heritable( BMPR2,ALK-1,Endogin...) | #Heritable( BMPR2,ALK-1,Endogin...) | ||
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#Persistent Pulmonary Hypertension of the newborn | #Persistent Pulmonary Hypertension of the newborn | ||
==Pulmonary Venous Hypertension or pulmonary hypertension owing to left heart disease== | ==Class 2: Pulmonary Venous Hypertension or pulmonary hypertension owing to left heart disease== | ||
#Systolic Dysfunction. | #Systolic Dysfunction. | ||
#Diastolic dysfunction. | #Diastolic dysfunction. | ||
#Valvular disease. | #Valvular disease. | ||
==Pulmonary Hypertension associated with disorders of the respiratory system and/or Hypoxemia== | ==Class 2: Pulmonary Hypertension associated with disorders of the respiratory system and/or Hypoxemia== | ||
#Chronic Obstructive Pulmonary Disease. | #Chronic Obstructive Pulmonary Disease. | ||
#Interstitial Lung Disease | #Interstitial Lung Disease | ||
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#Developmental abnormalities. | #Developmental abnormalities. | ||
==Pulmonary Hypertension due to chronic thrombotic and/or embolic disease== | ==Class 4: Pulmonary Hypertension due to chronic thrombotic and/or embolic disease== | ||
==Pulmonary Hypertension due to disorders directly affecting the pulmonary vasculature== | ==Class 5: Pulmonary Hypertension due to disorders directly affecting the pulmonary vasculature== | ||
#Hematologic disorders: Myeloproliferative disorders,splenectomy,polycythemia vera. | #Hematologic disorders: Myeloproliferative disorders,splenectomy,polycythemia vera. | ||
#Systemic disorders: Sarcoidosis,Langerhan cell Histiocytosis, Neurofibromatosis, Vasculitis. | #Systemic disorders: Sarcoidosis,Langerhan cell Histiocytosis, Neurofibromatosis, Vasculitis. | ||
#Metabolic disorders: Glycogen storage diseases, Gaucher disease, Thyroid disorders. | #Metabolic disorders: Glycogen storage diseases, Gaucher disease, Thyroid disorders. | ||
#Miscellaneous: Tumor obstruction, Fibrosing mediastinitis, chronic renal failure on dialysis. | #Miscellaneous: Tumor obstruction, Fibrosing mediastinitis, chronic renal failure on dialysis. | ||
Revision as of 12:35, 8 September 2011
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Etiologies of Pulmonary Hypertension organized under the Updated Clinical Classification of Pulmonary Hypertension(Dana point,2008)
Class 1: Pulmonary Aterial Hypertension
- Idiopathic PAH
- Heritable( BMPR2,ALK-1,Endogin...)
- Drug and toxin induced.
- Connective tissue diseases
- HIV
- Portal Hypertension
- Congenital heart diseases
- Schistosomiasis
- Chronic hemolytic anemia.
- Persistent Pulmonary Hypertension of the newborn
Class 2: Pulmonary Venous Hypertension or pulmonary hypertension owing to left heart disease
- Systolic Dysfunction.
- Diastolic dysfunction.
- Valvular disease.
Class 2: Pulmonary Hypertension associated with disorders of the respiratory system and/or Hypoxemia
- Chronic Obstructive Pulmonary Disease.
- Interstitial Lung Disease
- Pulmonary diseases with mixed restrictive and obstructive patterns.
- Obstructive sleep apnea.
- High Altitude(chronically).
- Developmental abnormalities.
Class 4: Pulmonary Hypertension due to chronic thrombotic and/or embolic disease
Class 5: Pulmonary Hypertension due to disorders directly affecting the pulmonary vasculature
- Hematologic disorders: Myeloproliferative disorders,splenectomy,polycythemia vera.
- Systemic disorders: Sarcoidosis,Langerhan cell Histiocytosis, Neurofibromatosis, Vasculitis.
- Metabolic disorders: Glycogen storage diseases, Gaucher disease, Thyroid disorders.
- Miscellaneous: Tumor obstruction, Fibrosing mediastinitis, chronic renal failure on dialysis.