Alagille syndrome laboratory tests: Difference between revisions
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====Biochemical Evaluation | {{Alagille syndrome}} | ||
{{CMG}} | |||
==Overview== | |||
In addition to various imaging modalities, laboratory tests may be conducted evaluating the bilirubin levels. A liver biopsy may also be conducted on the bile duct to further supplement bilirubin testing. | |||
==Laboratory Tests== | |||
===Biochemical Evaluation=== | |||
Total Bilirubin >6.5 mg/dL, Conjugated Bilirubin >4.5 mg/dL, and cholesterol >520 mg/dL in children younger than 5 years of age are likely be associated with severe liver disease in later life <ref name="pmid20421762">{{cite journal| author=Kamath BM, Munoz PS, Bab N, Baker A, Chen Z, Spinner NB et al.| title=A longitudinal study to identify laboratory predictors of liver disease outcome in Alagille syndrome. | journal=J Pediatr Gastroenterol Nutr| year= 2010 | volume= 50 | issue= 5 | pages= 526-30 | pmid=20421762 | doi=10.1097/MPG.0b013e3181cea48d |pmc=PMC2861305 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20421762 }} </ref>. | Total Bilirubin >6.5 mg/dL, Conjugated Bilirubin >4.5 mg/dL, and cholesterol >520 mg/dL in children younger than 5 years of age are likely be associated with severe liver disease in later life <ref name="pmid20421762">{{cite journal| author=Kamath BM, Munoz PS, Bab N, Baker A, Chen Z, Spinner NB et al.| title=A longitudinal study to identify laboratory predictors of liver disease outcome in Alagille syndrome. | journal=J Pediatr Gastroenterol Nutr| year= 2010 | volume= 50 | issue= 5 | pages= 526-30 | pmid=20421762 | doi=10.1097/MPG.0b013e3181cea48d |pmc=PMC2861305 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20421762 }} </ref>. | ||
===Liver Biopsy=== | |||
A liver [[biopsy]] may indicate too few [[bile duct]]s (bile duct paucity). | A liver [[biopsy]] may indicate too few [[bile duct]]s (bile duct paucity). | ||
===X ray=== | |||
An unusual butterfly shape of the bones of the spinal column that can be seen in an [[x-ray]] | An unusual butterfly shape of the bones of the spinal column that can be seen in an [[x-ray]] | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Pediatrics]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Genetic disorders]] | |||
[[Category:Rare diseases]] | |||
[[Category:Hepatology]] | |||
[[Category:Mature chapter]] | |||
{{WH}} | |||
{{WS}} |
Revision as of 17:22, 23 September 2011
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In addition to various imaging modalities, laboratory tests may be conducted evaluating the bilirubin levels. A liver biopsy may also be conducted on the bile duct to further supplement bilirubin testing.
Laboratory Tests
Biochemical Evaluation
Total Bilirubin >6.5 mg/dL, Conjugated Bilirubin >4.5 mg/dL, and cholesterol >520 mg/dL in children younger than 5 years of age are likely be associated with severe liver disease in later life [1].
Liver Biopsy
A liver biopsy may indicate too few bile ducts (bile duct paucity).
X ray
An unusual butterfly shape of the bones of the spinal column that can be seen in an x-ray
References
- ↑ Kamath BM, Munoz PS, Bab N, Baker A, Chen Z, Spinner NB; et al. (2010). "A longitudinal study to identify laboratory predictors of liver disease outcome in Alagille syndrome". J Pediatr Gastroenterol Nutr. 50 (5): 526–30. doi:10.1097/MPG.0b013e3181cea48d. PMC 2861305. PMID 20421762.