Alagille syndrome overview: Difference between revisions
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{{CMG}} | |||
==Overview== | |||
'''Alagille syndrome''' is a multisystem [[genetic disorder]] that affects the [[liver]], [[heart]], [[eyes]],[[face]], [[skeleton]], [[kidneys]] and [[vascular system]]. Problems associated with the disorder generally become evident in infancy or early childhood. The patients have a characteristic facial appearance. The disorder is inherited in an [[autosomal dominant]] pattern, and the estimated prevalence of Alagille syndrome is 1 in every 70,000 live births. The clinical features are highly variable even within the family. | '''Alagille syndrome''' is a multisystem [[genetic disorder]] that affects the [[liver]], [[heart]], [[eyes]],[[face]], [[skeleton]], [[kidneys]] and [[vascular system]]. Problems associated with the disorder generally become evident in infancy or early childhood. The patients have a characteristic facial appearance. The disorder is inherited in an [[autosomal dominant]] pattern, and the estimated prevalence of Alagille syndrome is 1 in every 70,000 live births. The clinical features are highly variable even within the family. | ||
==References== | |||
{{reflist|2}} | |||
[[Category:Pediatrics]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Genetic disorders]] | |||
[[Category:Rare diseases]] | |||
[[Category:Hepatology]] | |||
[[Category:Mature chapter]] | |||
{{WH}} | |||
{{WS}} | |||
Revision as of 17:12, 23 September 2011
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Alagille syndrome is a multisystem genetic disorder that affects the liver, heart, eyes,face, skeleton, kidneys and vascular system. Problems associated with the disorder generally become evident in infancy or early childhood. The patients have a characteristic facial appearance. The disorder is inherited in an autosomal dominant pattern, and the estimated prevalence of Alagille syndrome is 1 in every 70,000 live births. The clinical features are highly variable even within the family.