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| <small>'''''Synonyms / Brand Names:''''' Amitriptyline Hydrochloride, Amitriptyline HCL, Amitriprolidine, Amitriptylin, Amitryptiline, Amitryptyline, Amytriptiline, Adepress, Adepril, Amitid, Amitril, Damilan, Damilen, dAmitriptyline, Elanil, Elavil, Endep, Flavyl, Hexathane, Horizon, Lantron, Laroxil, Laroxyl, Lentizol, Proheptadiene, Redomex, Saroten, Sarotex, Seroten, Sylvemid, Triptanol, Triptilin, Triptisol, Tryptanol, Tryptizol</small>
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| | {{Amitriptyline}} |
| | {{CMG}}; {{AE}} |
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| {{CMG}}
| | '''''For patient information about Amitriptyline, click [[Amitriptyline (patient information)|here]].''''' |
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| ==Dosing and Administration==
| | {{SB}} Amitriptyline Hydrochloride, Amitriptyline HCL, Amitriprolidine, Amitriptylin, Amitryptiline, Amitryptyline, Amytriptiline, Adepress, Adepril, Amitid, Amitril, Damilan, Damilen, dAmitriptyline, Elanil, Elavil, Endep, Flavyl, Hexathane, Horizon, Lantron, Laroxil, Laroxyl, Lentizol, Proheptadiene, Redomex, Saroten, Sarotex, Seroten, Sylvemid, Triptanol, Triptilin, Triptisol, Tryptanol, Tryptizol |
| For outpatients, 75 mg of Amitriptyline HCl a day in divided doses is usually satisfactory. If necessary, this may be increased to a total of 150 mg per day. Increases are made preferably in the late afternoon and/or bedtime doses. A sedative effect may be apparent before the antidepressant effect is noted, but an adequate therapeutic effect may take as long as 30 days to develop.
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| An alternate method of initiating therapy in outpatients is to begin with 50 to 100 mg Amitriptyline HCl at bedtime. This may be increased by 25 or 50 mg as necessary in the bedtime dose to a total of 150 mg per day.
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| Hospitalized patients may require 100 mg a day initially. This can be increased gradually to 200 mg a day if necessary. A small number of hospitalized patients may need as much as 300 mg a day.
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| [[{{PAGENAME}}#FDA Package Insert Resources|FDA Package Insert Resources]]
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| <br></font size><small>Indications, Contraindications, Side Effects, Drug Interactions, etc.</small><font size="4"><br>
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| [http://www.pace-med-apps.com/gfrcalc.htm Calculate Creatine Clearance]
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| <br></font size><small>On line calculator of your patients Cr Cl by a variety of formulas.</small><font size="4"><br>
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| [http://home.earthlink.net/~sensei11/convert.htm Convert pounds to Kilograms]
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| <br></font size><small>On line calculator of your patients weight in pounds to Kg for dosing estimates.</small><font size="4"><br>
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| <br> [[{{PAGENAME}}#Publication Resources|Publication Resources]]
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| <br></font size><small>Recent articles, WikiDoc State of the Art Review, Textbook Information</small><font size="4"><br>
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| [[{{PAGENAME}}#Trial Resources|Trial Resources]]
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| <br></font size><small>Ongoing Trials, Trial Results</small><font size="4"><br>
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| [[{{PAGENAME}}#Guidelines & Evidence Based Medicine Resources|Guidelines & Evidence Based Medicine Resources]]
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| <br></font size><small>US National Guidelines, Cochrane Collaboration, etc.</small><font size="4"><br>
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| [[{{PAGENAME}}#Media Resources|Media Resources]]
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| <br></font size><small>Slides, Video, Images, MP3, Podcasts, etc.</small><font size="4"><br><br>
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| [[{{PAGENAME}}#Patient Resources|Patient Resources]]
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| <br></font size><small>Discussion Groups, Handouts, Blogs, News, etc.</small><font size="4"><br>
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| [[{{PAGENAME}}#International Resources|International Resources]]
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| <br></font size><small>en Español</small><font size="4"><br>
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| ==FDA Package Insert Resources== | | ==Overview== |
| [[{{PAGENAME}} indications|Indications]]
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| [[{{PAGENAME}} contraindications|Contraindications]]
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| [[{{PAGENAME}} side effects|Side Effects]]
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| [[{{PAGENAME}} drug interactions|Drug Interactions]]
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| [[{{PAGENAME}} precautions|Precautions]]
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| [[{{PAGENAME}} overdose|Overdose]]
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| [[{{PAGENAME}} instructions for administration|Instructions for Administration]]
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| [[{{PAGENAME}} how supplied|How Supplied]]
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| [[{{PAGENAME}} pharmacokinetics and molecular data|Pharmacokinetics and Molecular Data]]
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| [http://www.fda.gov/medwatch/safety/2008/Apr_PI/AugmentinES_PI.pdf FDA label]
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| [http://google2.fda.gov/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&x=0&y=0&client=FDA&site=FDA&lr=&proxystylesheet=FDA&output=xml_no_dtd&getfields=* FDA on {{PAGENAME}}]
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| ==Publication Resources== | | ==Category== |
| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Most Recent Articles on {{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}]
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| [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}%20AND%20systematic%5Bsb%5D Review Articles on {{PAGENAME}}]
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+AND+%28%28N+Engl+J+Med%5Bta%5D%29+OR+%28Lancet%5Bta%5D%29+OR+%28BMJ%5Bta%5D%29%29 Articles on {{PAGENAME}} in N Eng J Med, Lancet, BMJ]
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| [[{{PAGENAME}} detailed information|WikiDoc State of the Art Review]]
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| [http://books.google.com/books?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search&sa=N&tab=gp Textbook Information on {{PAGENAME}}]
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| ==Trial Resources== | | ==FDA Package Insert== |
| [http://clinicaltrials.gov/search/open/condition={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Ongoing Trials with {{PAGENAME}} at Clinical Trials.gov]
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+AND+%28randomized+controlled+trial%5BPublication+Type%5D+OR+%28randomized%5BTitle%2FAbstract%5D+AND+controlled%5BTitle%2FAbstract%5D+AND+trial%5BTitle%2FAbstract%5D%29%29 Trial Results with {{PAGENAME}}]
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| ==Guidelines & Evidence Based Medicine Resources== | | ====AMITRIPTYLINE HYDROCHLORIDE tablet, film coated==== |
| [http://www.guideline.gov/search/searchresults.aspx?Type=3&txtSearch={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&num=20 US National Guidelines Clearinghouse on {{PAGENAME}}]
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:({{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}) AND (Cochrane Database Syst Rev[ta])}} Cochrane Collaboration on {{PAGENAME}}]
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:({{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}) AND (Cost effectiveness)}} Cost Effectiveness of {{PAGENAME}}]
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| </font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
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| ==Media Resources==
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| [http://www.google.com/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+ppt&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a Powerpoint Slides on {{PAGENAME}}]
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| [http://images.google.com/images?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&sa=N&tab=wi Images of {{PAGENAME}}]
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| [http://www.google.com/search?hl=en&client=firefox-a&rls=org.mozilla%3Aen-US%3Aofficial&hs=hPo&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+podcasts+OR+MP3&btnG=Search Podcasts & MP3s on {{PAGENAME}}]
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| [http://video.google.com/videosearch?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&um=1&sa=N&tab=fv# Videos on {{PAGENAME}}]
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| ==Patient Resources==
| | ''' [[Amitriptyline hydrochloride indications and usage|Indications and Usage]]''' |
| [[{{PAGENAME}} (patient information)|Patient Information from National Library of Medicine]] | | '''| [[Amitriptyline hydrochloride dosage and administration|Dosage and Administration]]''' |
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| | '''| [[Amitriptyline hydrochloride dosage forms and strengths|Dosage Forms and Strengths]]''' |
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| | '''| [[Amitriptyline hydrochloride contraindications|Contraindications]]''' |
| [http://www.google.com/search?hl=en&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+more:for_patients&cx=disease_for_patients&sa=N&oi=cooptsr&resnum=0&ct=col3&cd=1 Patient Resources on {{PAGENAME}}] | | '''| [[Amitriptyline hydrochloride warnings and precautions|Warnings and Precautions]]''' |
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| | '''| [[Amitriptyline hydrochloride adverse reactions|Adverse Reactions]]''' |
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| | '''| [[Amitriptyline hydrochloride drug interactions|Drug Interactions]]''' |
| [http://groups.google.com/groups/search?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search Discussion Groups on {{PAGENAME}}] | | '''| [[Amitriptyline hydrochloride use in specific populations|Use in Specific Populations]]''' |
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| | '''| [[Amitriptyline hydrochloride overdosage|Overdosage]]''' |
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| | '''| [[Amitriptyline hydrochloride description|Description]]''' |
| [http://www.google.com/search?hl=en&client=firefox-a&rls=org.mozilla:en-US:official&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+more:patient_handouts&cx=disease_for_health_professionals&sa=N&oi=coopctx&resnum=0&ct=col1&cd=3 Patient Handouts on {{PAGENAME}}] | | '''| [[Amitriptyline hydrochloride clinical pharmacology|Clinical Pharmacology]]''' |
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| | '''| [[Amitriptyline hydrochloride nonclinical toxicology|Nonclinical Toxicology]]''' |
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| | '''| [[Amitriptyline hydrochloride clinical studies|Clinical Studies]]''' |
| [http://blogsearch.google.com/blogsearch?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&sa=N&tab=wb Blogs on {{PAGENAME}}] | | '''| [[Amitriptyline hydrochloride how supplied storage and handling|How Supplied/Storage and Handling]]''' |
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| | '''| [[Amitriptyline hydrochloride patient counseling information|Patient Counseling Information]]''' |
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| | '''| [[Amitriptyline hydrochloride labels and packages|Labels and Packages]]''' |
| [http://news.google.com/news?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&sa=N&tab=wn {{PAGENAME}} in the News] | |
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| [http://finance.google.com/finance?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search&sa=N&tab=te {{PAGENAME}} in the Marketplace] | |
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| ==International Resources== | | ==Mechanism of Action== |
| [http://www.google.com/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+en+espanol&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a {{PAGENAME}} en Español]
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| | ==References== |
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| | {{Reflist|2}} |
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| {{FDA}}
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| [[Category:Drugs]] | | [[Category:Drugs]] |