'''Dalteparin''' is a [[low molecular weight heparin]]. It is marketed as '''Fragmin''' by [[Pfizer|Pfizer Inc]]. Like other low molecular weight heparins, dalteparin is used for prophylaxis or treatment of [[deep vein thrombosis]] and [[pulmonary embolism]].
[[{{PAGENAME}} drug interactions|Drug Interactions]]
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[[{{PAGENAME}} precautions|Precautions]]
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[[{{PAGENAME}} overdose|Overdose]]
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[[{{PAGENAME}} instructions for administration|Instructions for Administration]]
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[[{{PAGENAME}} how supplied|How Supplied]]
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[[{{PAGENAME}} pharmacokinetics and molecular data|Pharmacokinetics and Molecular Data]]
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[http://www.fda.gov/cder/foi/label/2007/020287s035lbl.pdf FDA label]
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==Publication Resources==
The CLOT study, published in 2003, showed that in patients with malignancy and acute [[venous thromboembolism]], dalteparin was more effective than [[warfarin]] in reducing the risk of recurrent embolic events.<ref>{{cite journal | author=Lee AY, Levine MN, Baker RI, Bowden C, [[Ajay Kakkar, Baron Kakkar|Kakkar AK]], Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M | title=Low-molecular-weight heparin versus a Coumadin for the prevention of recurrent venous thromboembolism in patients with cancer | journal=N Engl J Med | year=2003 | pages=146–53 | volume=349 | issue=2 | pmid=12853587 | doi=10.1056/NEJMoa025313}}</ref> Dalteparin is not superior to [[unfractionated heparin]] in preventing blood clots.<ref>{{cite journal|author=The PROTECT Investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group|title=Dalteparin versus unfractionated heparin in critically ill patients|year=2011|doi=10.1056/NEJMoa1014475}}</ref>
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[[Dalteparin detailed information|WikiDoc State of the Art Review]]
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==Trial Resources==
Heparins are cleared by the kidneys, but studies have shown that dalteparin does not accumulate even if kidney function is reduced.<ref>{{cite journal | author=Douketis J, Cook D, Meade M ''et al.'' | title=Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin | journal=Arch Intern Med | year=2008 | volume=168 | issue=16 | pmid=18779469 | pages=1805–1812 | doi=10.1001/archinte.168.16.1805}}</ref>
[http://clinicaltrials.gov/search/open/condition={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Ongoing Trials with {{PAGENAME}} at Clinical Trials.gov]
==Category==
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==Guidelines & Evidence Based Medicine Resources==
Anticoagulants:Heprin group
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==Media Resources==
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==Patient Resources==
FRAGMIN<sup>®</sup>
[[{{PAGENAME}} (patient information)|Patient Information from National Library of Medicine]]
==FDA Package Insert==
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==International Resources==
'''| [[Dalteparin indications and usage|Indications and Usage]]'''
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'''| [[Dalteparin dosage and administration|Dosage and Administration]]'''
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'''| [[Dalteparin dosage forms and strengths|Dosage Forms and Strengths]]'''
The CLOT study, published in 2003, showed that in patients with malignancy and acute venous thromboembolism, dalteparin was more effective than warfarin in reducing the risk of recurrent embolic events.[1] Dalteparin is not superior to unfractionated heparin in preventing blood clots.[2]
Heparins are cleared by the kidneys, but studies have shown that dalteparin does not accumulate even if kidney function is reduced.[3]
↑Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M (2003). "Low-molecular-weight heparin versus a Coumadin for the prevention of recurrent venous thromboembolism in patients with cancer". N Engl J Med. 349 (2): 146–53. doi:10.1056/NEJMoa025313. PMID12853587.CS1 maint: Multiple names: authors list (link)
↑The PROTECT Investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group (2011). "Dalteparin versus unfractionated heparin in critically ill patients". doi:10.1056/NEJMoa1014475.
↑Douketis J, Cook D, Meade M; et al. (2008). "Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin". Arch Intern Med. 168 (16): 1805–1812. doi:10.1001/archinte.168.16.1805. PMID18779469.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)