Diazoxide detailed information: Difference between revisions

Diazoxide detailed information
Clinical data
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	Oral, intravenous
ATC code	C02DA01 (WHO) V03AH01 (WHO);
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Protein binding	90%
Metabolism	Hepatic oxidation and sulfate conjugation
Elimination half-life	21-45 hours
Excretion	Renal
Identifiers
	IUPAC name 7-chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide;
CAS Number	364-98-7;
PubChem CID	3019;
DrugBank	APRD00914;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C8H7ClN2O2S
Molar mass	230.672 g/mol

VisualWikitext

Revision as of 00:43, 9 August 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

It is used as a vasodilator in the treatment of acute hypertension, and also to decrease the secretion of insulin in disease states such as insulinoma (a tumor producing insulin).

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 '''Diazoxide''' is a [[potassium channel]] activator, which causes local relaxation in [[smooth muscle]] by increasing membrane [[Semipermeable membrane|permeability]] to potassium [[ion]]s. This switches off voltage-gated [[calcium]] ion channels which inhibits the generation of an [[action potential]].

v t e Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents	Template:Navbox subgroup
Vasodilators	Diazoxide • hydrazinophthalazine (Hydralazine, Dihydralazine, Endralazine, Cadralazine) • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensives	serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan) • MAOI (Pargyline) • THI (Metirosine)
Diuretics	Template:Navbox subgroup

Clinical data

Pregnancy category	AU: C US: C (Risk not ruled out)
Routes of administration	Oral, intravenous
ATC code	C02DA01 (WHO) V03AH01 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding	90%
Metabolism	Hepatic oxidation and sulfate conjugation
Elimination half-life	21-45 hours
Excretion	Renal
Identifiers
IUPAC name 7-chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
CAS Number	364-98-7
PubChem CID	3019
DrugBank	APRD00914
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₈H₇ClN₂O₂S
Molar mass	230.672 g/mol

Diazoxide detailed information: Difference between revisions

Revision as of 00:43, 9 August 2012

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