Loxapine (oral): Difference between revisions

Jump to navigation Jump to search
m (Protected "Loxapine": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite)))
 
m (Robot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +))
Line 21: Line 21:
{{CMG}}
{{CMG}}


{{EH}}
 


'''Loxapine''' (sold as '''Loxapac'''®, '''Loxitane'''®) is a [[typical antipsychotic]] [[medication]], used primarily in the treatment of [[schizophrenia]]. It is a member of the [[dibenzoxazepine]] class and as a [[dibenzazepine]] [[Derivative (chemistry)|derivative]], it is structurally related to [[clozapine]] (which belongs to the chemically closely akin class of [[dibenzodiazepines]]). Several researchers have argued that Loxapine may behave as an [[atypical antipsychotic]] (PMID 10340686).
'''Loxapine''' (sold as '''Loxapac'''®, '''Loxitane'''®) is a [[typical antipsychotic]] [[medication]], used primarily in the treatment of [[schizophrenia]]. It is a member of the [[dibenzoxazepine]] class and as a [[dibenzazepine]] [[Derivative (chemistry)|derivative]], it is structurally related to [[clozapine]] (which belongs to the chemically closely akin class of [[dibenzodiazepines]]). Several researchers have argued that Loxapine may behave as an [[atypical antipsychotic]] (PMID 10340686).

Revision as of 17:02, 9 August 2012

Loxapine (oral)
Clinical data
ATC code
Pharmacokinetic data
Elimination half-lifeOral-4 hours
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC18H18ClN3O
Molar mass327.808 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Loxapine (sold as Loxapac®, Loxitane®) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. It is a member of the dibenzoxazepine class and as a dibenzazepine derivative, it is structurally related to clozapine (which belongs to the chemically closely akin class of dibenzodiazepines). Several researchers have argued that Loxapine may behave as an atypical antipsychotic (PMID 10340686).

Loxapine may be metabolized by N-demethylation to amoxapine, a tetracyclic antidepressant (PMID 1860915).

Side effects

The most significant side-effects of loxapine are excessive salivation and indifference to surroundings. Loxapine, if administered to normal persons causes emotional quietening and insensitivity. In persons with psychosis, it may control aggressive behaviour and restlessness, and reduce the severity of hallucinations and delusions. Other Side effects include tardive dyskinesia, neuroleptic malignant syndrome, extrapyramidal side effects, tremor, gynecomastia and sedation.

Dosage

The typical starting dosage is 10mg twice daily; usual dose range 30-50mg twice daily; maximum recommended dosage is 250mg per day.

External links