Mevastatin: Difference between revisions
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Latest revision as of 17:24, 9 August 2012
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
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| Formula | C23H36O6 |
| Molar mass | 408.534 g/mol |
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Ongoing Trials on Mevastatin at Clinical Trials.gov Clinical Trials on Mevastatin at Google
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US National Guidelines Clearinghouse on Mevastatin
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Patient resources on Mevastatin Discussion groups on Mevastatin Patient Handouts on Mevastatin Directions to Hospitals Treating Mevastatin Risk calculators and risk factors for Mevastatin
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Causes & Risk Factors for Mevastatin |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Mevastatin, compactin, ML-236B is a hypolipidemic agent that belongs to the statins class.
It was the first compound isolated in the 1970s during research into HMG-CoA reductase inhibitors produced by a mould Penicillium citrinum.
Nowadays, Mevastatin is not used in therapy of hyperlipidemias because of multiple side effects but it is the only source for production of other statin - pravastatin.
Mechanisms of Action
Mevastatin inhibits isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1 nM)1 and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans.[1] It causes cells to arrest early in the G1 phase. [2] [3]
Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.
References
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- Cardiology
- Statins
- Drugs