Nefazodone

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Synonyms / Brand Names: Nefazodona, Nefazodone Hcl, Nefazodone hydrochloride, Nefazodonum, Dutonin, Serzone

Dosing and Administration

The recommended starting dose for Nefazodone hydrochloride tablets is 200 mg/day, administered in two divided doses (BID). In the controlled clinical trials establishing the antidepressant efficacy of Nefazodone, the effective dose range was generally 300 to 600 mg/day. Consequently, most patients, depending on tolerability and the need for further clinical effect, should have their dose increased. Dose increases should occur in increments of 100 mg/day to 200 mg/day, again on a BID schedule, at intervals of no less than 1 week. As with all antidepressants, several weeks on treatment may be required to obtain a full antidepressant response.

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Adapted from the FDA Package Insert. Template:WH