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| {{CMG}}
| | #REDIRECT [[Propranolol#Adult Indications and Dosage]] |
| __NOTOC__
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| __NOEDITSECTION__
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| ==Angina==
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| ===Adults===
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| PO 80 to 320 mg/day in 2 to 4 divided doses or 80 mg/day of sustained-release medication (max, 320 mg/day).
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| ==[[Arrhythmias]]==
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| ===Adults===
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| PO 10 to 30 mg 3 to 4 times daily before meals and at bedtime.
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| ==[[Arrhythmias]] (Life-Threatening)==
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| ===Adults===
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| IV 1 to 3 mg at rate of 1 mg/min; may repeat after 2 min; give subsequent doses every 4 h.
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| ==Essential Tremor==
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| ===Adults===
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| PO 40 mg twice daily initially; titrate to response. The maintenance dose is 120 to 320 mg/day in 2 to 3 divided doses (max, 320 mg/day).
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| ==[[Hypertension]]==
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| ===Adults===
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| PO The initial dose is 40 mg twice daily initially or 80 mg sustained-release medication/day; titrate to response. The usual maintenance dose is 120 to 240 mg/day in 2 to 3 divided doses or 120 to 160 mg/day sustained-release medication, except for InnoPran XL (do not exceed 120 mg/day). Do not exceed 640 mg/day.
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| ===Children===
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| PO 0.5 mg/kg twice daily; titrate every 3 to 5 days to max dose of 16 mg/kg/day.
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| ==[[Hypertrophic Aortic Stenosis]]==
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| ===Adults===
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| PO 20 to 40 mg 3 to 4 times daily before meals and at bedtime or 80 to 160 mg sustained-release medication once daily.
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| ==[[Migraine]]==
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| ===Adults===
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| PO 80 mg in divided doses daily or once daily (sustained release); titrate to response (max dose, 240 mg/day); discontinue after 6 wk if no response.
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| ==MI==
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| ===Adults===
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| PO 180 to 240 mg/day in 3 to 4 divided doses up to 240 mg/day.
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| ==[[Pheochromocytoma]]==
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| ===Adults===
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| PO 60 mg/day for 3 days prior to surgery, given with alpha-blocker.
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| ==General Advice==
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| Immediate-release and extended-release dose forms may not be interchangeable on a mg to mg basis. Be prepared to retitrate dose to maintain desired therapeutic effect.
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| ===Immediate-release tablets===
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| * Administer without regard to meals but administer with food if GI upset occurs.
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| ===Extended-release capsules===
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| * Administer prescribed dose once daily (InnoPran XL should be administered at bedtime).
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| * Administer without regard to meals but administer with food if GI upset occurs. Administer consistently either with or without food.
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| * Have patient swallow capsules whole; do not crush, chew, break, or open capsule.
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| ===Oral solution===
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| * Measure and administer prescribed dose using dosing syringe, spoon, or cup.
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| * Administer without regard to meals but administer with food if GI upset occurs.
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| ===Concentrated oral solution===
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| * Use supplied dropper to measure prescribed dose. Squeeze dropper contents into a liquid (e.g., water, juice, soda, soda-like beverage) or semisolid food (e.g., applesauce, pudding) and mix by gently stirring the mixture. Entire amount of mixture should be consumed immediately.
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| * Do not prepare mixtures ahead of time and store for future use.
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| ===Injection===
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| * For IV administration only. Not for intradermal, subcutaneous, IM, or intraarterial administration.
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| * Do not administer if solution is discolored or cloudy, or if particulate matter is noted.
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| * Administer IV bolus dose at rate not exceeding 1 mg (1 mL) per minute. A second dose may be administered 2 min later if response to first dose is inadequate. Additional drug should not be given in less than 4 h.
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| * Discard any unused solution. Do not save for future use.
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| {{FDA}}
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| [[Category:Drugs]]
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