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==[[Ramipril (patient information)|For patient information, click here]]==
==[[Ramipril (patient information)|For patient information, click here]]==

Revision as of 15:32, 20 August 2012

Ramipril detailed information
Clinical data
Pregnancy
category
  • D
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability28%
Protein binding73% (ramipril)
56% (ramiprilat)
MetabolismHepatic, to ramiprilat
Elimination half-life2 to 4 hours
ExcretionRenal (60%) and fecal (40%)
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC23H32N2O5
Molar mass416.511 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


For patient information, click here

Overview

Ramipril (marketed as Tritace/Ramace or Altace) is an angiotensin-converting enzyme (ACE) inhibitor, used to treat hypertension and congestive heart failure. ACE inhibitors lower the production of angiotensin II, therefore relaxing arterial muscles while at the same time enlarging the arteries, allowing the heart to pump blood more easily, and increasing blood flow due to more blood being pumped into and through larger passageways.

Ramipril is a prodrug and is converted to the active metabolite ramiprilat by liver esterase enzymes. Ramiprilat is mostly excreted by the kidneys. The half-life of ramiprilat is variable (3-16 hours), and is prolonged by heart and liver failure, as well as kidney failure.

Indications

Indications for its use include:

Cautions

  • Do not take potassium supplements without seeking medical advice.
  • Do not take during pregnancy

Contraindications

Renovascular disease, severe renal impairment (especially in patients with one kidney or with bilateral renal artery stenosis), volume-depleted patients, history of angioedema while on an ACE inhibitor, pregnancy, hypotension.

Side-effects

  • may cause swelling of the mouth, tongue, or throat
  • low blood sugar in patients taking other medicine for diabetes which shows as sweating or shakiness
  • persistent dry cough, dizziness, and light-headedness due to low blood pressure.

Dose

  • 2.5 to 20 mg per day
  • initial dose of 1.25mg per day

See also

External links


Template:ACE inhibitors

de:Ramipril hr:Ramipril


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