Thiofentanyl

Thiofentanyl

File:Thiofentanyl.svg
Clinical data
Synonyms	Thiofentanyl
Legal status
Legal status	CA: Schedule I UK: Class A US: Schedule I
Identifiers
IUPAC name N-phenyl-N-[1-(2-thiophen-2-ylethyl)-4-piperidyl]propanamide
CAS Number	60771-38-2
PubChem CID	62380
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C20H26N2OS
Molar mass	342.499 g/mol

Thiofentanyl is an opioid analgesic that is an analogue of fentanyl.

Thiofentanyl was sold briefly on the black market in the early 1980s, before the introduction of the Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared. Thiofentanyl is made with the same synthetic route as fentanyl, but by substituting 2-(2-bromoethyl)thiophene for phenethyl bromide in the synthesis.

Thiofentanyl has similar effects to fentanyl. Side effects of fentanyl analogues are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression which can be life-threatening.