Prilocaine: Difference between revisions

Prilocaine
Clinical data
Pregnancy; category	B (U.S.);
ATC code	N01BB04 (WHO) ;
Pharmacokinetic data
Protein binding	55%
Metabolism	Hepatic and renal
Elimination half-life	10-150 minutes, longer with impaired hepatic or renal function
Identifiers
	IUPAC name N-(2-methylphenyl)-2-propylamino-propanamide;
CAS Number	721-50-6;
PubChem CID	4906;
DrugBank	APRD00180;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C13H20N2O
Molar mass	220.311 g/mol

Revision as of 12:05, 25 June 2014

Prilocaine (Template:PronEng) is a local anesthetic of the amino amide type. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA). As it has low cardiac toxicity, it is commoly used for intravenous regional anaesthesia (IVRA).

In some patients, a metabolite of prilocaine may cause the unusual side-effect of methaemoglobinaemia.

Maximum dosage for dental use: 6.0mg/kg (2.7mg/lb), with a maximum dose of 400mg.

v t e Anesthetics: Local anesthetics (N01B)
Esters of aminobenzoic acid	Amylocaine, Benzocaine, Butacaine, Chloroprocaine, Dimethocaine, Meprylcaine, Orthocaine, Propoxycaine, Procaine, Proparacaine, Risocaine, Tetracaine
Amides	Articaine, Bupivacaine, Carticaine, Cinchocaine, Etidocaine, Levobupivacaine, Lidocaine, Mepivacaine, Prilocaine, Ropivacaine, Trimecaine
Esters of benzoic acid	Cocaine, Piperocaine
Other	Hexylcaine, Iontocaine, Lidocaine/prilocaine

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Clinical data

Pregnancy category	B (U.S.)
ATC code	N01BB04 (WHO)
Pharmacokinetic data
Protein binding	55%
Metabolism	Hepatic and renal
Elimination half-life	10-150 minutes, longer with impaired hepatic or renal function
Identifiers
IUPAC name N-(2-methylphenyl)-2-propylamino-propanamide
CAS Number	721-50-6
PubChem CID	4906
DrugBank	APRD00180
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₃H₂₀N₂O
Molar mass	220.311 g/mol