Efonidipine: Difference between revisions

Efonidipine
Clinical data
Routes of; administration	Oral
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 2-(phenyl-(phenylmethyl)amino)ethyl 5-(5,5-dimethyl-2-oxo-1,3-dioxa-2λ5-phosphacyclohex-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;
CAS Number	111011-63-3;
PubChem CID	119171;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C34H38N3O7P
Molar mass	631.65 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN (CC4=CC=CC=C4)C5=CC=CC=C5;

Latest revision as of 02:07, 9 August 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Efonidipine (INN) is a dihydropyridine calcium channel blocker marketed by Shionogi & Co. of Japan. It was launched in 1995, under the brand name Landel.

It has also been studied in atherosclerosis^[1] and acute renal failure.^[2]

↑ Toyoda K, Kitahara M, Yamashita T; et al. (1994). "[Effect of efonidipine hydrochloride (NZ-105), a new dihydropyridine calcium antagonist, on the experimental atherosclerosis in cholesterol-fed rabbits]". Nippon Yakurigaku Zasshi (in Japanese). 103 (5): 231–9. PMID 8188119. Unknown parameter |month= ignored (help)
↑ Shudo C, Masuda Y, Sugita H, Tanaka S, Tomita K (1994). "Effects of efonidipine hydrochloride (NZ-105), a new calcium antagonist, against acute renal failure in rats". Gen. Pharmacol. 25 (7): 1451–8. PMID 7896060. Unknown parameter |month= ignored (help)

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 {{CMG}}
-{{EH}}
 '''Efonidipine''' ([[International Nonproprietary Name|INN]]) is a [[dihydropyridine]] [[calcium channel blocker]] marketed by Shionogi & Co. of [[Japan]]. It was launched in [[1995]], under the brand name '''Landel'''.

Clinical data

Routes of administration	Oral
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 2-(phenyl-(phenylmethyl)amino)ethyl 5-(5,5-dimethyl-2-oxo-1,3-dioxa-2λ5-phosphacyclohex-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
CAS Number	111011-63-3
PubChem CID	119171
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₃₄H₃₈N₃O₇P
Molar mass	631.65 g/mol
3D model (JSmol)	Interactive image
SMILES CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN (CC4=CC=CC=C4)C5=CC=CC=C5