Oxatomide: Difference between revisions

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{{drugbox |
{{Drugbox
| IUPAC_name =  
| Verifiedfields = changed
| image = Oxatomide.png  
| verifiedrevid = 462266871
| IUPAC_name = 1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-1,3-dihydro-2''H''-benzimidazol-2-one
| image = Oxatomide.png
 
<!--Clinical data-->
| tradename = Tinset, Cedlips, Atoxan
| Drugs.com = {{drugs.com|international|oxatomide}}
| pregnancy_category = 
| legal_status = Rx-only
| routes_of_administration = Oral
 
<!--Pharmacokinetic data-->
| bioavailability = 
| metabolism = 
| elimination_half-life = 
| excretion = 
 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 60607-34-3
| CAS_number = 60607-34-3
| ATC_prefix = R06
| ATC_prefix = R06
| ATC_suffix = AE06
| ATC_suffix = AE06
| PubChem = 615
| PubChem = 4615
| DrugBank =  
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4454
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = J31IL9Z2EE
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01773
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 13828
 
<!--Chemical data-->
| C=27 | H=30 | N=4 | O=1  
| C=27 | H=30 | N=4 | O=1  
| molecular_weight = 426.553 g/mol
| molecular_weight = 426.553 g/mol
| bioavailability =  
| smiles = O=C2Nc1ccccc1N2CCCN5CCN(C(c3ccccc3)c4ccccc4)CC5
| protein_bound =  
| InChI = 1/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
| metabolism =  
| InChIKey = BAINIUMDFURPJM-UHFFFAOYAU
| elimination_half-life =  
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| excretion =
| StdInChI = 1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| pregnancy_US =  <!-- A / B            / C / D / X -->
| StdInChIKey = BAINIUMDFURPJM-UHFFFAOYSA-N
| pregnancy_category = 
| legal_AU =      <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK =      <!-- GSL        / P      / POM / CD -->
| legal_US =      <!-- OTC                  / Rx-only  -->
| legal_status =  
| routes_of_administration =  
}}
}}
'''Oxatomide''' is a [[piperazine]] [[antihistamine]]. It was discovered at [[Janssen Pharmaceutica]] in [[1975]].


{{Antihistamines}}
'''Oxatomide''' (R35443) is a [[first-generation antihistamine]] of the [[phenylpiperazine]] class.<ref name="pmid6138301">{{cite journal | author = Ohmori K, Ishii H, Nito M, Shuto K, Nakamizo N | title = [Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators] | language = Japanese | journal = Nippon Yakurigaku Zasshi. Folia Pharmacologica Japonica | volume = 81 | issue = 5 | pages = 399–409 |date=May 1983 | pmid = 6138301 | doi = 10.1254/fpj.81.399| url = }}</ref> It was discovered at [[Janssen Pharmaceutica]] in 1975. Oxatomide lacks any [[anticholinergic]] effects.<ref name="pmid6138301">{{cite journal | author = Ohmori K, Ishii H, Nito M, Shuto K, Nakamizo N | title = [Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators] | language = Japanese | journal = Nippon Yakurigaku Zasshi. Folia Pharmacologica Japonica | volume = 81 | issue = 5 | pages = 399–409 |date=May 1983 | pmid = 6138301 | doi = 10.1254/fpj.81.399| url = }}</ref> In addition to its [[H1 receptor|H<sub>1</sub> receptor]] [[receptor_antagonist|antagonism]], it also possesses [[antiserotonergic]] actions.<ref name="pmid6138301">{{cite journal | author = Ohmori K, Ishii H, Nito M, Shuto K, Nakamizo N | title = [Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators] | language = Japanese | journal = Nippon Yakurigaku Zasshi. Folia Pharmacologica Japonica | volume = 81 | issue = 5 | pages = 399–409 |date=May 1983 | pmid = 6138301 | doi = 10.1254/fpj.81.399| url = }}</ref>


==See also==
*[[Piperazine]]


{{drug-stub}}
==References==
{{Reflist}}
 
{{Antihistamines}}
{{Histaminergics}}
{{Serotonergics}}
{{Piperazines}}


[[th:ออกซาโทไมด์]]
[[Category:H1 receptor antagonists]]
[[Category:H1 receptor antagonists]]
[[Category:Piperazines]]
[[Category:Piperazines]]
{{WikiDoc Help Menu}}
[[Category:Benzimidazoles]]
{{WikiDoc Sources}}
[[Category:Ureas]]
[[Category:Lactams]]
[[Category:Janssen Pharmaceutica]]
[[Category:Belgian inventions]]
 
 
{{respiratory-system-drug-stub}}

Revision as of 15:26, 10 April 2015

Oxatomide
Clinical data
Trade namesTinset, Cedlips, Atoxan
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC27H30N4O
Molar mass426.553 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Oxatomide (R35443) is a first-generation antihistamine of the phenylpiperazine class.[1] It was discovered at Janssen Pharmaceutica in 1975. Oxatomide lacks any anticholinergic effects.[1] In addition to its H1 receptor antagonism, it also possesses antiserotonergic actions.[1]

See also

References

  1. ↑ 1.0 1.1 1.2 Ohmori K, Ishii H, Nito M, Shuto K, Nakamizo N (May 1983). "[Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators]". Nippon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 81 (5): 399–409. doi:10.1254/fpj.81.399. PMID 6138301.

Template:Piperazines


Template:Respiratory-system-drug-stub

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