Thiolutin: Difference between revisions
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'''Thiolutin''' is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit ''in vitro'' RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in ''Saccharomyces cerevisiae'' and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to [[vitronectin]] and thus suppresses tumor cell-induced angiogenesis in vivo. | '''Thiolutin''' is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit ''in vitro'' RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in ''Saccharomyces cerevisiae'' and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to [[vitronectin]] and thus suppresses tumor cell-induced angiogenesis in vivo. | ||
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Latest revision as of 16:51, 20 August 2012
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C8H8N2O2S2 |
| Molar mass | 228.293 g/mol |
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Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.
Thiolutin is formed in submerged fermentation by several strains of Streptomycetes (source: Fermentek product page)
Synonyms: farcinicin, propiopyvothine, acetopyrrothine
Some sources erroneously specify "aureothricin" as a synonym of thiolutin. Aureothricin is an antibiotic very similar to Thiolutin, and is created as a by-product during the Thiolutin fermentation.
References
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- E number from Wikidata
- ECHA InfoCard ID from Wikidata
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- Antibiotics
- Organic disulfides