Suramin: Difference between revisions

Jump to navigation Jump to search
Newer edit →
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Protected "Suramin": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite))
 
Gerald Chi (talk | contribs)
CMEAdmin, Bureaucrats, bureaucrats, editnews, exportpages, interwiki, nocaptcha, nukepages, smwadministrator, Administrators, Widget editors
17,702 edits
mNo edit summary
Line 1: Line 1:
{{Drugbox|
{{Drugbox|
|IUPAC_name =  
|IUPAC_name =  
| image = Suramin.svg
| image = Suramin.png
| CAS_number=
| CAS_number=
| ATC_prefix=P01
| ATC_prefix=P01
Line 18: Line 18:
| routes_of_administration=  
| routes_of_administration=  
}}
}}
__NOTOC__
{{CMG}}
==Overview==
'''Suramin''' is a medicinal [[medication|drug]] developed by [[Oskar Dressel]] and [[Richard Kothe]] of [[Bayer]], [[Germany]] in [[1916]]. It is used for treatment of human [[sleeping sickness]], [[onchocerciasis]] and other diseases caused by [[trypanosome]]s and [[worm]]s.  It is under investigation as treatment for [[prostate cancer]].
'''Suramin''' is a medicinal [[medication|drug]] developed by [[Oskar Dressel]] and [[Richard Kothe]] of [[Bayer]], [[Germany]] in [[1916]]. It is used for treatment of human [[sleeping sickness]], [[onchocerciasis]] and other diseases caused by [[trypanosome]]s and [[worm]]s.  It is under investigation as treatment for [[prostate cancer]].


Line 45: Line 49:


{{Agents against leishmaniasis and trypanosomiasis}}
{{Agents against leishmaniasis and trypanosomiasis}}
[[Category:Anthelmintics]]
[[Category:Anthelmintics]]
[[Category:Ureas]]
[[Category:Ureas]]
 
[[Category:Drug]]
[[de:Suramin]]
[[he:סוראמין]]

Revision as of 19:24, 4 April 2015

Suramin
Clinical data
ATC code
Identifiers
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC51H40N6O23S6
Molar mass1297.29

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Suramin is a medicinal drug developed by Oskar Dressel and Richard Kothe of Bayer, Germany in 1916. It is used for treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms. It is under investigation as treatment for prostate cancer.

Chemistry

The molecular formula of suramin is C51H34N6O23S6. It is a symmetric molecule in the center of which lies urea, NH-CO-NH. Suramin contains 8 benzene rings, 4 of which are fused in paires (naphthalene), 4 amide groups in addition to the one of urea and six sulfonate groups. When given as drug it usually contains six sodium ions that form a salt with the six sulfonate groups.

Dosing

Suramin is admistered by a single weekly intravenous injection for six weeks. The dose per injection is 1 g.

Adverse reactions

The most frequent adverse reactions are nausea and vomiting. About 90% of patients will get an urticarial rash (like a nettle or poison ivy-type rash) that disappears in a few days without needing to stop treatment. There is a greater than 50% chance of adrenal cortical damage, but only a smaller proportion will require lifelong corticosteroid replacement. It is common for patients to get a tingling or crawling sensation of the skin with suramin. Suramin will cause clouding of the urine which is harmless: patients should be warned of this to avoid them becoming alarmed.

Kidney damage and exfoliative dermatitis occur less commonly.

Research

Suramin is also used in research as a broad-spectrum antagonist of P2 receptors (ATP receptors) and agonist of Ryanodine receptors.

Manufacturing and availability

Suramin is manufactured by Bayer in Germany as Germanin®. Each vial contains 1g of suramin powder to be reconstituted for injection.

External links

Template:Agents against leishmaniasis and trypanosomiasis

Retrieved from "https://www.wikidoc.org/index.php?title=Suramin&oldid=1082670"