Levodropropizine: Difference between revisions

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Levodropropizine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	R05DB27 (WHO) ;
Pharmacokinetic data
Protein binding	11-14%
Excretion	83% via urine within 96 h
Identifiers
	IUPAC name (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol;
CAS Number	99291-25-5 ;
PubChem CID	65859;
ChemSpider	59270 ;
UNII	3O31P6T4G3;
KEGG	D08119 ;
ChEBI	CHEBI:82722 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C13H20N2O2
Molar mass	236.31 g/mol
3D model (JSmol)	Interactive image;
	SMILES O[C@@H](CN2CCN(c1ccccc1)CC2)CO;
	InChI InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1 ; Key:PTVWPYVOOKLBCG-ZDUSSCGKSA-N ;
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VisualWikitext

Latest revision as of 15:27, 10 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Levodropropizine is a cough suppressant. It is the levo isomer of dropropizine. It acts as a peripheral antitussive, with no action in the central nervous system.^[1] It does not cause side effects such as constipation or respiratory depression which can be produced by opioid antitussives such as codeine and its derivatives.

References

↑ PMID 22269875 (PMID 22269875)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand

Template:Piperazines Template:Cough and cold preparations

Template:Respiratory-system-drug-stub

[1] PMID 22269875 (PMID 22269875)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand

[1]

@@ Line 1: / Line 1: @@
-{{drugbox
+{{Drugbox
-| IUPAC_name        = (2''S'')-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
+| Verifiedfields = changed
-| image             = Levodropropizine.svg
+| verifiedrevid = 451369843
-| CAS_number        = 99291-24-4
+| IUPAC_name = (2''S'')-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
-| ATC_prefix        = R05
+| image =Levodropropizine.png
-| ATC_suffix        = DB27
-| PubChem           = 65859
+<!--Clinical data-->
-| DrugBank          =
+| tradename =
-| C = 13 | H = 20 | N = 2 | O = 2
+| Drugs.com = {{drugs.com|international|levodropropizine}}
-| molecular_weight  = 236.31 g/mol
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
-| bioavailability   =
+| pregnancy_US = <!-- A / B            / C / D / X -->
-| protein_bound     =
+| pregnancy_category =
-| metabolism        =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| elimination_half-life =
+| legal_CA = <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
-| excretion         =
+| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| legal_US = <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| legal_status =
-| pregnancy_category=
+| routes_of_administration =
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+<!--Pharmacokinetic data-->
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
+| bioavailability =
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
+| protein_bound = 11-14%
-| legal_status      =
+| metabolism =
-| routes_of_administration =
+| elimination_half-life =
+| excretion = 83% via urine within 96 h
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
+| CAS_number = 99291-25-5
+| ATC_prefix = R05
+| ATC_suffix = DB27
+| PubChem = 65859
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 59270
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 3O31P6T4G3
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D08119
+| ChEBI_Ref = {{ebicite|changed|EBI}}
+| ChEBI = 82722
+<!--Chemical data-->
+| C=13 | H=20 | N=2 | O=2
+| molecular_weight = 236.31 g/mol
+| smiles = O[C@@H](CN2CCN(c1ccccc1)CC2)CO
+| InChI = 1/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1
+| InChIKey = PTVWPYVOOKLBCG-ZDUSSCGKBV
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = PTVWPYVOOKLBCG-ZDUSSCGKSA-N
 }}
-'''Levodropropizine''' is a [[cough suppressant]].
+__Notoc__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Levodropropizine''' is a [[cough suppressant]]. It is the [[levo isomer]] of [[dropropizine]]. It acts as a peripheral antitussive, with no action in the [[central nervous system]].<ref>{{cite pmid|22269875}}</ref> It does not cause [[side effects]] such as [[constipation]] or [[respiratory depression]] which can be produced by [[opioid]] antitussives such as [[codeine]] and its derivatives.
+==References==
+{{reflist|2}}
+{{Piperazines}}
+{{Cough and cold preparations}}
+[[Category:Antitussives]]
+[[Category:Piperazines]]
+[[Category:Diols]]
+[[Category:Drug]]
-{{pharmacology-stub}}
-{{Cough and cold preparations, peripheral antitusive, no action on cns unlike codeine and hence does not cause constipation. also does not suppress the respiratory system like dextromethorphan}}
-[[Category: Antitussives]]
+{{respiratory-system-drug-stub}}
-{{WikiDoc Help Menu}}
-{{WikiDoc Sources}}

Levodropropizine: Difference between revisions

Latest revision as of 15:27, 10 April 2015

Overview

References

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