Aminoglutethimide: Difference between revisions
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'''Aminoglutethimide''' blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme desmolase, thus inhibits synthesis of all hormonally active steroids. It can be used in conjunction with other drugs for treatment of steroid-producing adrenocortical cancer. | '''Aminoglutethimide''' blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme desmolase, thus inhibits synthesis of all hormonally active steroids. It can be used in conjunction with other drugs for treatment of steroid-producing adrenocortical cancer. | ||
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{{Sex hormones}} | {{Sex hormones}} | ||
[[Category:Aromatase inhibitors]] | [[Category:Aromatase inhibitors]] | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 22:04, 8 August 2012
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| Clinical data | |
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| Pregnancy category | |
| Routes of administration | Oral |
| ATC code | |
| Pharmacokinetic data | |
| Bioavailability | >95% |
| Metabolism | Hepatic |
| Elimination half-life | 12.5 ± 1.6 hours |
| Excretion | Renal |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C13H16N2O2 |
| Molar mass | 232.278 g/mol |
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Aminoglutethimide blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme desmolase, thus inhibits synthesis of all hormonally active steroids. It can be used in conjunction with other drugs for treatment of steroid-producing adrenocortical cancer.
Its major side effects are liver toxicity, inhibition of cortisol in the human body, and it may also cause hypothyroidism. Since cortisol helps break down muscle, aminoglutethimide is used by bodybuilders in a steroid cycle.
It is still used to suppress corticosteroid production in Cushing's Syndrome.
See also
External links
- Pages with script errors
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Chemical articles with unknown parameter in Infobox drug
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- Aromatase inhibitors
- Endocrinology