Estrone

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Estrone

Clinical data
ATC code	G03CA07 (WHO) G03CC04 (WHO)
Pharmacokinetic data
Protein binding	>95%
Elimination half-life	19 hours
Identifiers
IUPAC name 3-hydroxy-13-methyl- 6,7,8,9,11,12,13,14,15,16- decahydrocyclopenta[a]phenanthren- 17- one
CAS Number	53-16-7
PubChem CID	5870
DrugBank	APRD00588
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C18H22O2
Molar mass	270.366 g/mol
Melting point	254.5 °C (490.1 °F)

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List of terms related to Estrone

Estrone (also oestrone) is an estrogenic hormone secreted by the ovary.

Estrone is one of the three estrogens, which also include estriol and estradiol. Estrone is the least prevalent of the three hormones, estradiol being prevalent almost always in a female body, estriol being prevalent primarily during pregnancy. Estrone is relevant to health and disease due to its conversion to estrone sulfate, a long-lived derivative of estrone. Estrone sulfate acts as a pool of estrone which can be converted as needed to the more active estradiol.

Synthesis

Estrone is synthesized via aromatase from androstenedione, a derivative of progesterone. The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring. This reaction is similar to the conversion of testosterone to estradiol.

Additional images

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  Androstenedione converting to estrone.
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  Steroidogenesis