Mixed angina pectoris

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

Mixed or variable threshold angina pectoris is a syndrome in which there is substantial variation in the magnitude of physical activity or provocation that induces anginal chest pain.

Pathophysiology

• Dynamic vasoconstriction which superimposed on fixed atherosclerotic coronary artery obstructions has been postulated as the underlying pathophysiologic mechanism for the variable exercise threshold.

Diagnosis

Symptoms

• The essential clinical feature of mixed angina is a substantial variation in the degree of physical activity that induces angina.
• These group of patients may also experience rest or nocturnal angina on certain occasions.
• Angina may also occur on exposure to cold, during emotional stress, or after meals.

Treatment

• The treatment is the same as chronic stable angina.