Pulmonary embolism pathophysiology: Difference between revisions
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In cases when more than 2/3rd of the [[pulmonary artery]] is occluded, Right ventricle is forced to: | In cases when more than 2/3rd of the [[pulmonary artery]] is occluded, Right ventricle is forced to: | ||
#Generate a [[systolic pressure]] in excess of 50 mmHg | #Generate a [[ systolic blood pressure|systolic pressure]] in excess of 50 mmHg | ||
#Maintain a [[mean pulmonary artery pressure]] approximating 40 mmHg | #Maintain a [[mean pulmonary artery pressure]] approximating 40 mmHg | ||
to preserve pulmonary perfusion, failing which it can lead to Right heart failure<ref name="pmid6488744">{{cite journal| author=Benotti JR, Dalen JE| title=The natural history of pulmonary embolism. | journal=Clin Chest Med | year= 1984 | volume= 5 | issue= 3 | pages= 403-10 | pmid=6488744 | doi= | pmc= | url= }} </ref>. | to preserve pulmonary perfusion, failing which it can lead to Right heart failure<ref name="pmid6488744">{{cite journal| author=Benotti JR, Dalen JE| title=The natural history of pulmonary embolism. | journal=Clin Chest Med | year= 1984 | volume= 5 | issue= 3 | pages= 403-10 | pmid=6488744 | doi= | pmc= | url= }} </ref>. | ||
Revision as of 16:05, 16 November 2011
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Pulmonary Embolism Microchapters |
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Diagnosis |
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Pulmonary Embolism Assessment of Probability of Subsequent VTE and Risk Scores |
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Treatment |
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Follow-Up |
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Special Scenario |
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Trials |
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Case Studies |
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Pulmonary embolism pathophysiology On the Web |
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Directions to Hospitals Treating Pulmonary embolism pathophysiology |
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Risk calculators and risk factors for Pulmonary embolism pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]
Overview
Pulmonary embolism (PE) occurs when there is an acute obstruction of the pulmonary artery (or one of its branches). Most often this is due to a venous thrombus (blood clot from a vein), which has been dislodged from its site of formation and embolizes to the arterial blood supply of one of the lungs. This process is termed thromboembolism.
Iliofemoral veins are the source of most clinically recognized PE. It can cause death and significant disability.
The following video explains the pathophysiology of DVT and its most common complication, PE. <youtube v=gGrDAGN5pC0/>
Thrombus travels to the lung, and depending on its size, produce variable outcomes.
- Large thrombus: lodge at the bifurcation of the main pulmonary artery or lobar branches, and causes hemodynamic compromise.
- Small thrombus: travel distally and initiate an inflammatory response adjacent to the parietal pleura causing pleuritis and pleuritic chest pain.
Gas exchange abnormalities, if present, happen due to a mix of the following factors:
- Mechanical obstruction of the vascular bed.
- Alterations in the ventilation to perfusion ratio.
- Release of inflammatory mediators causing atelectasis and surfactant dysfunction.
Mechanism
| Thrombus causes Vascular Obstruction/Occlusion | |||||||||||||||||||||||||||||||||
| Hypoxia | Release of Inflamatory mediators | ||||||||||||||||||||||||||||||||
| vasoconstriction | |||||||||||||||||||||||||||||||||
| Increases Pulmonary vascular resistances | |||||||||||||||||||||||||||||||||
| Decreases Right ventricular outflow | |||||||||||||||||||||||||||||||||
| Cardiac output decreases | |||||||||||||||||||||||||||||||||
| Hypotension | |||||||||||||||||||||||||||||||||
In cases when more than 2/3rd of the pulmonary artery is occluded, Right ventricle is forced to:
- Generate a systolic pressure in excess of 50 mmHg
- Maintain a mean pulmonary artery pressure approximating 40 mmHg
to preserve pulmonary perfusion, failing which it can lead to Right heart failure[1].
Patients with underlying cardiopulmonary disease experience more substantial deterioration in Cardiac Output than otherwise healthy individuals. Also, right ventricular failure following PE is more common in patients with coexisting coronary artery disease.