Pulmonary hypertension epidemiology and demographics: Difference between revisions
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{{Pulmonary hypertension}} | {{Pulmonary hypertension}} | ||
{{CMG}} '''Assistant Editor(s)-in-Chief:''' [[User:Ralph Matar|Ralph Matar]], | {{CMG}} '''Assistant Editor(s)-in-Chief:''' [[User:Ralph Matar|Ralph Matar]], | ||
== Overview == | |||
==Epidemiology and Demographics== | |||
== | ===Incidence=== | ||
== | |||
While previously considered a rare disease, the most recent evidence from a French registry suggests that the '''[[incidence]]''' of new cases of pulmonary arterial hypertension is 2-3 cases per million per year. | While previously considered a rare disease, the most recent evidence from a French registry suggests that the '''[[incidence]]''' of new cases of pulmonary arterial hypertension is 2-3 cases per million per year. | ||
==Prevalence== | ===Prevalence=== | ||
The '''[[prevalence]]''' is about 15 per million. | The '''[[prevalence]]''' is about 15 per million. | ||
==Age== | ===Age=== | ||
*Pulmonary Hypertension usually develops between the ages of 20 and 60, but it can occur at any age. | *Pulmonary Hypertension usually develops between the ages of 20 and 60, but it can occur at any age. | ||
==Gender== | ===Gender=== | ||
*'''Idiopathic pulmonary hypertension'''(IPAH) which is more prevalent in women(3x more common), was considered the most common type of Pulmonary arterial hypertension in a French registry. | *'''Idiopathic pulmonary hypertension'''(IPAH) which is more prevalent in women(3x more common), was considered the most common type of Pulmonary arterial hypertension in a French registry. | ||
==Genetics== | ===Genetics=== | ||
*'''Familial PAH''' often results from a [[mutation]] in the bone morphogenic protein receptor-2 (BMPR2) and is inherited as an [[autosomal dominant]] disease with incomplete [[penetrance]] and anticipation. | *'''Familial PAH''' often results from a [[mutation]] in the bone morphogenic protein receptor-2 (BMPR2) and is inherited as an [[autosomal dominant]] disease with incomplete [[penetrance]] and anticipation. | ||
==Incidence of Associated Diseases== | ===Incidence of Associated Diseases=== | ||
*PAH is also associated with <ref>ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension</ref>: | *PAH is also associated with <ref>ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension</ref>: | ||
#[[Congenital heart disease]](30% of untreated) | #[[Congenital heart disease]](30% of untreated) | ||
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{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 18:25, 27 August 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assistant Editor(s)-in-Chief: Ralph Matar,
Overview
Epidemiology and Demographics
Incidence
While previously considered a rare disease, the most recent evidence from a French registry suggests that the incidence of new cases of pulmonary arterial hypertension is 2-3 cases per million per year.
Prevalence
The prevalence is about 15 per million.
Age
- Pulmonary Hypertension usually develops between the ages of 20 and 60, but it can occur at any age.
Gender
- Idiopathic pulmonary hypertension(IPAH) which is more prevalent in women(3x more common), was considered the most common type of Pulmonary arterial hypertension in a French registry.
Genetics
- Familial PAH often results from a mutation in the bone morphogenic protein receptor-2 (BMPR2) and is inherited as an autosomal dominant disease with incomplete penetrance and anticipation.
Incidence of Associated Diseases
- PAH is also associated with [1]:
- Congenital heart disease(30% of untreated)
- Connective tissue diseases(12% of patients with scleroderma and upto 21% of patients with rheumatoid arthritis)
- HIV (0.5%)
- Portal hypertension(2-6%)
- Sickle cell disease(20 to 40%).
- Systemic lupus erythematosus(4 to 14%)
- Hemoglobinopathies
- Myeloproliferative disorders.
- Drugs and toxins
- Diet pills such as Fen-Phen produced an annual incidence of 25-50 per million per year.
- Mortality rate is 5.2-5.4 per 100000 and was more common in African-Americans and women.
- The most common cause of hospitilization is heart failure
- The most common cause of death is right ventricular failure and not chronic lower respiratory disease as was once thought.
References
- ↑ ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension