Heparin-induced thrombocytopenia differential diagnosis

Heparin-induced thrombocytopenia
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Overview

Heparin-induced thrombocytopenia is diagnosed when the platelet count falls by > 50% typically after 5-10 days of heparin therapy. It should be differentiated by other causes of thrombocytopenia like hemolytic uremic syndrome, Thrombotic thrombocytopenia and others.

Differential diagnosis

Diagnosis of Heparin-induced thrombocytopenia is mainly done with the help of lab tests. A decrease in platelet count by > 50% typically after 5-10 days of heparin therapy leads to a diagnosis of HIT. Thus, it should be differentiated from other causes of thrombocytopenia like

• Disseminated Intravascular Coagulation
• Thrombotic Thrombocytopenic Purpura
• Hemolytic-Uremic Syndrome
• Immune Thrombocytopenic Purpura
• Drug-Induced Thrombocytopenia
• Posttransfusion Thrombocytopenia
• Systemic Lupus Erythematosus