Glucocorticoid resistance: Difference between revisions

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Revision as of 20:33, 19 September 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

{{SK)) Cortisol resistance; glucocorticoid insensitivity; steroid hormone resistance; glucocorticoid receptor, steroid hormone insensitivity; overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations; elevations in circulating cortisol; mineralocorticoid excess; androgen excess

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Overview

Patients can be both resistant and hypersensitive to glucocorticoids.

In glucocorticoid resistance, the target tissue is unable to respond to glucocorticoids. The lack of responsiveness can be

Generalized or tissue-specific
Transient or permanent
Partial or complete
Compensated or noncompensated.

The presence of complete glucocorticoid resistance is fatal. Absence of functional glucocorticoid receptors (GRs) in GR -/- knockout mice is associated with death within hours.

Acknowledgements

The content on this page was first contributed by: C. Michael Gibson, M.S., M.D. Template:WH Template:WS

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+{{SK)) Cortisol resistance; glucocorticoid insensitivity; steroid hormone resistance; glucocorticoid receptor, steroid hormone insensitivity; overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations; elevations in circulating cortisol; mineralocorticoid excess; androgen excess
+Please help WikiDoc by adding more content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing.
 == Overview ==
 Patients can be both resistant and hypersensitive to glucocorticoids.
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 The presence of complete glucocorticoid resistance is fatal.  Absence of functional glucocorticoid receptors (GRs) in GR -/- knockout mice is associated with death within hours.
-'''''Related Key Words and Synonyms:'''''
-cortisol resistance, glucocorticoid insensitivity, steroid hormone resistance, glucocorticoid receptor, steroid hormone insensitivity, overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations, elevations in circulating cortisol, mineralocorticoid excess, androgen excess
-== Epidemiology and Demographics ==
-== Risk Factors ==
-== Screening ==
-== Pathophysiology & Etiology==
-== Molecular Biology ==
-== Genetics ==
-== Natural History ==
-== Diagnosis ==
-=== Differential Diagnosis ===
-=== History and Symptoms ===
-=== Physical Examination ===
-==== Appearance of the Patient ====
-====Vital Signs====
-====Skin====
-==== Eyes ====
-==== Ear Nose and Throat ====
-==== Heart ====
-==== Lungs ====
-==== Abdomen ====
-==== Extremities ====
-==== Neurologic ====
-==== Other ====
-=== Laboratory Findings ===
-==== Electrolyte and Biomarker Studies ====
-==== Electrocardiogram ====
-==== Chest X Ray ====
-==== MRI and CT ====
-==== Echocardiography or Ultrasound ====
-==== Other Imaging Findings ====
-=== Other Diagnostic Studies ===
-== Risk Stratification and Prognosis==
-== Treatment ==
-=== Pharmacotherapy ===
-==== Acute Pharmacotherapies ====
-==== Chronic Pharmacotherapies ====
-=== Surgery and Device Based Therapy ===
-==== Indications for Surgery ====
-==== Pre-Operative Assessment ====
-==== Post-Operative Management ====
-==== Transplantation ====
-=== Primary Prevention ===
-=== Secondary Prevention ===
-=== Cost-Effectiveness of Therapy ===
-=== Future or Investigational Therapies ===
-=="The Way I Like To Do It ..." Tips and Tricks From Clinicians Around The World==
-===Suggested Revisions to the Current Guidelines===
-==References==
-<biblio>
-</biblio>
 == Acknowledgements ==
 The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.
+{{WH}}
-Initial content for this page in some instances came from [http://www.wikipedia.org Wikipedia]
+{{WS}}
-'''List of contributors:'''
-== Suggested Reading and Key General References ==
-== Suggested Links and Web Resources ==
-== For Patients ==
-----
-{{WikiDoc Sources}}
 [[Category:Disease]]
 [[Category:Endocrinology]]
+[[Category:Needs content]]

Glucocorticoid resistance: Difference between revisions

Revision as of 20:33, 19 September 2012

Overview

Acknowledgements

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