Ewing's sarcoma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Michael Maddaleni, B.S.

Ewing's sarcoma Microchapters
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Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Ewing's sarcoma from other diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
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History and Symptoms
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Overview

Ewing's sarcoma is the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11.

Histology

The composition of Ewing's sarcoma consists of a homogeneous population of small round cells that have a high nuclear to cytoplasmic ratio. Also, the population of small round cells are arrayed in sheets.