Ewing's sarcoma pathophysiology: Difference between revisions
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==Histology== | ==Histology== | ||
The composition of Ewing's sarcoma consists of a [[homogeneous]] population of small round cells that have a high [[nuclear]] to [[cytoplasmic]] ratio. Also, the population of small round cells are arrayed in sheets. There is a presence of [[scant cytoplasms]] which are pale, [[vacuolated]], and are characterized by their faded boundaries.<ref name="pmid17272319">{{cite journal |author=Iwamoto Y |title=Diagnosis and treatment of Ewing's sarcoma |journal=[[Japanese Journal of Clinical Oncology]] |volume=37 |issue=2 |pages=79–89 |year=2007 |month=February |pmid=17272319 |doi=10.1093/jjco/hyl142 |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319 |accessdate=2012-01-04}}</ref> The [[nuclei]] have intense color which make them easily visible. [[Mitotic]] activity is usually low within these cells, and cytoplasmic [[glycogen]] is also usually present. | The composition of Ewing's sarcoma consists of a [[homogeneous]] population of small round cells that have a high [[nuclear]] to [[cytoplasmic]] ratio. Also, the population of small round cells are arrayed in sheets. There is a presence of [[scant cytoplasms]] which are pale, [[vacuolated]], and are characterized by their faded boundaries.<ref name="pmid17272319">{{cite journal |author=Iwamoto Y |title=Diagnosis and treatment of Ewing's sarcoma |journal=[[Japanese Journal of Clinical Oncology]] |volume=37 |issue=2 |pages=79–89 |year=2007 |month=February |pmid=17272319 |doi=10.1093/jjco/hyl142 |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319 |accessdate=2012-01-04}}</ref> The [[nuclei]] have intense color which make them easily visible. [[Mitotic]] activity is usually low within these cells, and cytoplasmic [[glycogen]] is also usually present. | ||
==References== | |||
{{Reflist|2}} | |||
Revision as of 16:15, 4 January 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Michael Maddaleni, B.S.
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Ewing's sarcoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Ewing's sarcoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Ewing's sarcoma pathophysiology |
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Risk calculators and risk factors for Ewing's sarcoma pathophysiology |
Overview
Ewing's sarcoma is the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11.
Histology
The composition of Ewing's sarcoma consists of a homogeneous population of small round cells that have a high nuclear to cytoplasmic ratio. Also, the population of small round cells are arrayed in sheets. There is a presence of scant cytoplasms which are pale, vacuolated, and are characterized by their faded boundaries.[1] The nuclei have intense color which make them easily visible. Mitotic activity is usually low within these cells, and cytoplasmic glycogen is also usually present.
References
- ↑ Iwamoto Y (2007). "Diagnosis and treatment of Ewing's sarcoma". Japanese Journal of Clinical Oncology. 37 (2): 79–89. doi:10.1093/jjco/hyl142. PMID 17272319. Retrieved 2012-01-04. Unknown parameter
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