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==Overview==
==Overview==
Most people are diagnosed without symptoms as the result of a routine blood test that returns a high white blood cell count, but as it advances CLL results in swollen lymph nodes, spleen, and liver, and eventually anemia and infections.


==History and Symptoms==
==History and Symptoms==
Most people are diagnosed without symptoms as the result of a routine blood test that returns a high white blood cell count, but as it advances CLL results in swollen lymph nodes, spleen, and liver, and eventually anemia and infections.
Presenting symtoms include:
 
* [[Fatigue]]
Uncommonly, CLL presents as enlargement of the lymph nodes without a high white blood cell count or no evidence of the disease in the blood. This is referred to as [[small lymphocytic lymphoma]].
* [[Fever]]
 
* [[ Bleeding]] - excessive
The increase in lymphocytes and precursors in the bone marrow impairs the production of other [[leucocytes]] causing a decrease in such cell types.
* [[Weight loss]]
* Muscle wasting
* [[Weakness]]
* Loss of appetite
* [[Night sweats]]
* [[Abdominal pain]]
* Frequent infections


A high beta-2-microglobulin level  may be seen and is an independent adverse prognostic factor for CR and OS. 


==References==
==References==

Revision as of 05:43, 7 August 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Most people are diagnosed without symptoms as the result of a routine blood test that returns a high white blood cell count, but as it advances CLL results in swollen lymph nodes, spleen, and liver, and eventually anemia and infections.

History and Symptoms

Presenting symtoms include:


References

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