Adrenal tumor pathophysiology: Difference between revisions
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==Tumors of the Adrenal Cortex== | |||
The [[adrenal cortex]] is composed of three distinct layers of [[endocrine]] cells which produce critical [[steroid hormone]]s. These include the [[glucocorticoid]]s which are critical for regulation of [[blood sugar]] and the [[immune system]], as well as response to physiological [[stress]], the [[mineralcorticoid]] [[aldosterone]], which regulates [[blood pressure]] and [[kidney]]function, and certain [[sex hormone]]s. Both [[benign]] and [[cancer|malignant]] tumors of the adrenal cortex may produce steroid hormones, with important clinical consequences. | |||
===Adrenocortical adenoma=== | |||
''Adrenocortical adenomas'', or adrenocortical "nodules", are small, benign tumors of the adrenal cortex which are extremely common (present in 1-10% of persons at autopsy). The clinical significance of these neoplasms is twofold. First, they have been detected as[[incidental finding]]s with increasing frequency in recent years, due to the increasing use of [[CT scan]]s and [[magnetic resonance imaging]] in a variety of medical settings. This can result in expensive additional testing and invasive procedures to rule out the slight possibility of an early [[adrenocortical carcinoma]]. Second, a minority of adrenocortical adenomas are "functional", meaning that they produce [[glucocorticoid]]s, [[mineralcorticoid]]s, and/or [[sex hormone|sex steroids]], resulting in endocrine disorders such as [[Cushing's syndrome]], [[Conn's syndrome]] (hyperaldosteronism), [[virilization]] of females, or[[feminization (biology)|feminization]] of males. Functional adrenocortical adenomas are surgically curable. | |||
===Adrenocortical carcinoma=== | |||
:''Main article: [[Adrenocortical carcinoma]] | |||
Adrenocortical carcinoma (ACC) is a rare, highly aggressive [[cancer]] of adrenal cortical cells, which may occur in children or adults. ACC's may be "functional", producing [[steroid hormone]]s and consequent [[endocrine]] dysfunction similar to that seen in many adrenocortical adenomas, but many are not. Due to their location deep in the [[retroperitoneum]], most adrenocortical carcinomas are not diagnosed until they have grown quite large. They frequently invade large vessels, such as the [[renal vein]] and[[inferior vena cava]], as well as [[metastasis|metastasizing]] via the [[lymphatics]] and through the [[blood]] to the [[lung]]s and other organs. The most effective treatment is [[surgery]], although this is not feasible for many patients, and the overall[[prognosis]] of the disease is poor. [[Chemotherapy]], [[radiation therapy]], and [[hormonal therapy (oncology)|hormonal therapy]]may also be employed in the treatment of this disease. | |||
==References== | ==References== | ||
Revision as of 19:51, 18 January 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Tumors of the Adrenal Cortex
The adrenal cortex is composed of three distinct layers of endocrine cells which produce critical steroid hormones. These include the glucocorticoids which are critical for regulation of blood sugar and the immune system, as well as response to physiological stress, the mineralcorticoid aldosterone, which regulates blood pressure and kidneyfunction, and certain sex hormones. Both benign and malignant tumors of the adrenal cortex may produce steroid hormones, with important clinical consequences.
Adrenocortical adenoma
Adrenocortical adenomas, or adrenocortical "nodules", are small, benign tumors of the adrenal cortex which are extremely common (present in 1-10% of persons at autopsy). The clinical significance of these neoplasms is twofold. First, they have been detected asincidental findings with increasing frequency in recent years, due to the increasing use of CT scans and magnetic resonance imaging in a variety of medical settings. This can result in expensive additional testing and invasive procedures to rule out the slight possibility of an early adrenocortical carcinoma. Second, a minority of adrenocortical adenomas are "functional", meaning that they produce glucocorticoids, mineralcorticoids, and/or sex steroids, resulting in endocrine disorders such as Cushing's syndrome, Conn's syndrome (hyperaldosteronism), virilization of females, orfeminization of males. Functional adrenocortical adenomas are surgically curable.
Adrenocortical carcinoma
- Main article: Adrenocortical carcinoma
Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer of adrenal cortical cells, which may occur in children or adults. ACC's may be "functional", producing steroid hormones and consequent endocrine dysfunction similar to that seen in many adrenocortical adenomas, but many are not. Due to their location deep in the retroperitoneum, most adrenocortical carcinomas are not diagnosed until they have grown quite large. They frequently invade large vessels, such as the renal vein andinferior vena cava, as well as metastasizing via the lymphatics and through the blood to the lungs and other organs. The most effective treatment is surgery, although this is not feasible for many patients, and the overallprognosis of the disease is poor. Chemotherapy, radiation therapy, and hormonal therapymay also be employed in the treatment of this disease.
References
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