Burkitt's lymphoma: Difference between revisions
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==Malignant B cell characteristics== | ==Malignant B cell characteristics== | ||
Malignant B cells have identical DNA recombinations of the V(D)J region of the Immunoglobin genes. This means that no increase in specificity of Antibody molecules is occurring in the malignant cells. These malignant cells are thus clonal populations and can be assayed for by using DNA probes specific for the regions where recombination is expected. Normal DNA will be characterized by two high concentration of identical germ line DNA V(D)J regions and endless, likely undetectable, non-germline Ig V(D)J DNA. Lymphoma cells have an additional high concentration of V(D)J DNA that is unlike the germline, indicating clonal populations of B Cells that are not undifferentiated B Cells (Germline DNA cells). Assays typically use the process of Electrophoresis and southern blot analysis to determine the existence of these characteristics. | Malignant B cells have identical DNA recombinations of the V(D)J region of the Immunoglobin genes. This means that no increase in specificity of Antibody molecules is occurring in the malignant cells. These malignant cells are thus clonal populations and can be assayed for by using DNA probes specific for the regions where recombination is expected. Normal DNA will be characterized by two high concentration of identical germ line DNA V(D)J regions and endless, likely undetectable, non-germline Ig V(D)J DNA. Lymphoma cells have an additional high concentration of V(D)J DNA that is unlike the germline, indicating clonal populations of B Cells that are not undifferentiated B Cells (Germline DNA cells). Assays typically use the process of Electrophoresis and southern blot analysis to determine the existence of these characteristics. | ||
==Treatment== | ==Treatment== | ||
Revision as of 15:19, 20 January 2012
| Burkitt's lymphoma | |
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| Burkitt lymphoma, touch prep, Wright stain | |
| ICD-10 | C83.7 |
| ICD-9 | 200.2 |
| ICD-O: | 9687/3 |
| OMIM | 113970 |
| DiseasesDB | 1784 |
| MeSH | D002051 |
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Burkitt's lymphoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Burkitt's lymphoma On the Web |
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American Roentgen Ray Society Images of Burkitt's lymphoma |
For patient information click here Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Microscopy
Consists of undifferentiated, small, noncleaved cells in broad sheets of tumor cells. Burkitt's lymphoma demonstrates starry sky appearance due to the macrophage ingestion of tumor cells.
Malignant B cell characteristics
Malignant B cells have identical DNA recombinations of the V(D)J region of the Immunoglobin genes. This means that no increase in specificity of Antibody molecules is occurring in the malignant cells. These malignant cells are thus clonal populations and can be assayed for by using DNA probes specific for the regions where recombination is expected. Normal DNA will be characterized by two high concentration of identical germ line DNA V(D)J regions and endless, likely undetectable, non-germline Ig V(D)J DNA. Lymphoma cells have an additional high concentration of V(D)J DNA that is unlike the germline, indicating clonal populations of B Cells that are not undifferentiated B Cells (Germline DNA cells). Assays typically use the process of Electrophoresis and southern blot analysis to determine the existence of these characteristics.
Treatment
Effect of the chemotherapy, as with all cancers, depends on the time of diagnosis. With faster growing cancers, such as this one, the cancer actually responds faster than with slower growing cancers.
Other treatments are immunotherapy, bone marrow transplants, surgery to remove the tumor, and radiotherapy.
Pathological Findings
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Burkitt lymphoma: bilateral eye involvement
Template:Chromosomal abnormalities