Pancytopenia differential diagnosis: Difference between revisions
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[[Pancytopenia]] usually requires a [[bone marrow]] [[biopsy]] in order to distinguish among different causes. | [[Pancytopenia]] usually requires a [[bone marrow]] [[biopsy]] in order to distinguish among different causes. | ||
In alphabetical order. <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref> | |||
===Congenital=== | ===Congenital=== | ||
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Revision as of 18:28, 20 January 2012
Template:Pancytopenia Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Pancytopenia is the pronounced reduction in the number of erythrocytes, all types of white blood cells and blood platelets that are circulating in the blood.
Pancytopenia is generally due to diseases affecting the bone marrow, although peripheral destruction of all lines of blood cells in hypersplenism (overactive spleen) is a recognized cause. Bone marrow problems causing pancytopenia include myelofibrosis, leukemia, aplastic anemia, and the malignant form of osteoporosis.
Chemotherapy for malignancies may also cause pancytopenia, if the drug or drugs used cause bone marrow suppression.
Increasingly, HIV (Human Immunodeficiency Virus) is itself a cause for pancytopenia. Rarely, drugs (antibiotics, anti hypertensive medication, heart medication) can cause pancytopenia.
Pancytopenia usually requires a bone marrow biopsy in order to distinguish among different causes.
In alphabetical order. [1] [2]
Congenital
- Cartilage hair hypoplasia
- Diamond-Blackfan syndrome
- Dubowitz syndrome
- Dyskeratosis congenita
- Familial aplastic anemia
- Fanconi's anemia
- Pearson syndrome
- Schwachman-Diamond syndrome
- TAR syndrome
Acquired
- Albers-Schonberg disease
- Banti's Syndrome
- Bone marrow tumor
- Cirrhosis
- Drugs/Toxins
- Felty's Syndrome
- Gaucher's Disease
- Graft-versus-host disease
- Infections
- Kala-Azar
- Leukemia
- Lymphoma
- Lymphoproliferative Disorders
- Myelodysplastic syndrome
- Myelofibrosis
- Niemann-Pick Disease
- Osteoporosis
- Pernicious anemia
- Reticulosis
- Sarcoidosis
- Thymoma
- Tuberculosis