Pheochromocytoma pathophysiology: Difference between revisions

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Revision as of 14:56, 11 September 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Traditionally it is known as the "10% tumor":

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+__NOTOC__
 {{Pheochromocytoma}}
 {{CMG}}
 ==Overview==
-A '''pheochromocytoma''' ('''phaeochromocytoma''' outside of the US) is a [[neuroendocrine tumor]] of the [[Adrenal medulla|medulla]] of the [[adrenal gland]]s (originating in the [[chromaffin cell]]s) or extra-adrenal chromaffin tissue which failed to involute after birth,<ref>{{cite book |author=Boulpaep, Emile L.; Boron, Walter F. |title=Medical physiology: a cellular and molecular approach |publisher=Saunders |location=Philadelphia |year=2003 |pages=1065 |isbn=0-7216-3256-4 |oclc= |doi=}}</ref> which secretes excessive amounts of [[catecholamine]]s, usually [[epinephrine]] and [[norepinephrine]].
-Extra-adrenal [[paragangliomas]] (often described as extra-adrenal pheochromocytomas) are closely related, though less common, tumors that originate in the [[ganglion|ganglia]] of the [[sympathetic nervous system]] and are named based upon the primary anatomical site of origin.
 ==Pathophysiology==
-==Additional images==
+Traditionally it is known as the "10% tumor":
+* bilateral disease is present in approximately 10% of patients
+* approximately 10% of tumours are malignant
+* approximately 10% are located in chromaffin tissue outside of the adrenal gland
+* Approximately 10% arise in childhood
+* Approximately 10% are familial
+* Approximately 10% recur after being resected
+* Approximately 10% patients do not have [[hypertension]] (Campbell's Urology)
+===Images===
 <gallery>