Pheochromocytoma physical examination: Difference between revisions
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(Created page with "{{Pheochromocytoma}} {{CMG}} ==Overview== A '''pheochromocytoma''' ('''phaeochromocytoma''' outside of the US) is a neuroendocrine tumor of the [[Adrenal medulla|medulla...") |
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{{Pheochromocytoma}} | {{Pheochromocytoma}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
==Physical Examination== | |||
*[[Elevated heart rate]] | |||
*[[Elevated blood pressure]], including paroxysmal (sporadic, episodic) high blood pressure, which sometimes can be more difficult to detect; another clue to the presence of pheochromocytoma is [[orthostatic hypotension]] (a fall in [[systolic blood pressure]]greater than 20 [[mmHg]] or a fall in [[diastolic blood pressure]] greater than 10 [[mmHg]] on making the patient stand) | |||
*Elevated blood glucose level (due primarily to catecholamine stimulation of [[lipolysis]] (breakdown of stored fat) leading to high levels of [[free fatty acids]] and the subsequent inhibition of glucose uptake by muscle cells. Further, stimulation of beta-adrenergic receptors leads to glycogenolysis and gluconeogenesis and thus elevation of blood glucose levels). | |||
A pheochromocytoma can also cause resistant [[arterial hypertension]]. A pheochromocytoma can be fatal if it causes [[malignant hypertension]], or severely [[high blood pressure]]. This hypertension is not well controlled with standard blood pressure medications. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 15:43, 11 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Physical Examination
- Elevated heart rate
- Elevated blood pressure, including paroxysmal (sporadic, episodic) high blood pressure, which sometimes can be more difficult to detect; another clue to the presence of pheochromocytoma is orthostatic hypotension (a fall in systolic blood pressuregreater than 20 mmHg or a fall in diastolic blood pressure greater than 10 mmHg on making the patient stand)
- Elevated blood glucose level (due primarily to catecholamine stimulation of lipolysis (breakdown of stored fat) leading to high levels of free fatty acids and the subsequent inhibition of glucose uptake by muscle cells. Further, stimulation of beta-adrenergic receptors leads to glycogenolysis and gluconeogenesis and thus elevation of blood glucose levels).
A pheochromocytoma can also cause resistant arterial hypertension. A pheochromocytoma can be fatal if it causes malignant hypertension, or severely high blood pressure. This hypertension is not well controlled with standard blood pressure medications.