Pheochromocytoma other diagnostic studies: Difference between revisions

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(Created page with "{{Pheochromocytoma}} {{CMG}} ==Overview== A '''pheochromocytoma''' ('''phaeochromocytoma''' outside of the US) is a neuroendocrine tumor of the [[Adrenal medulla|medulla...")
 
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==Overview==
==Overview==
 
==Other Diagnostic Studies==
A '''pheochromocytoma''' ('''phaeochromocytoma''' outside of the US) is a [[neuroendocrine tumor]] of the [[Adrenal medulla|medulla]] of the [[adrenal gland]]s (originating in the [[chromaffin cell]]s) or extra-adrenal chromaffin tissue which failed to involute after birth,<ref>{{cite book |author=Boulpaep, Emile L.; Boron, Walter F. |title=Medical physiology: a cellular and molecular approach |publisher=Saunders |location=Philadelphia |year=2003 |pages=1065 |isbn=0-7216-3256-4 |oclc= |doi=}}</ref> which secretes excessive amounts of [[catecholamine]]s, usually [[epinephrine]] and [[norepinephrine]].
One diagnostic test used in the past for a pheochromocytoma is to administer [[clonidine]], a centrally-acting alpha-2 agonist used to treat high blood pressure. Clonidine mimics catecholamines in the brain, causing it to reduce the activity of the sympathetic nerves controlling the adrenal medulla. A healthy adrenal medulla will respond to the [[Clonidine#Clonidine suppression test|Clonidine suppression test]] by reducing catecholamine production; the lack of a response is evidence of pheochromocytoma.
Extra-adrenal [[paragangliomas]] (often described as extra-adrenal pheochromocytomas) are closely related, though less common, tumors that originate in the [[ganglion|ganglia]] of the [[sympathetic nervous system]] and are named based upon the primary anatomical site of origin.
 
==References==
==References==
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[[Category:Endocrinology]]
[[Category:Endocrinology]]
[[Category:Oncology]]
[[Category:Oncology]]
[[de:Phäochromozytom]]
[[es:Feocromocitoma]]
[[fr:Phéochromocytome]]
[[it:Feocromocitoma]]
[[he:פאוכרומוציטומה]]
[[nl:Feochromocytoom]]
[[ja:褐色細胞腫]]
[[pl:Guz chromochłonny nadnerczy]]
[[sv:Feokromocytom]]
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Revision as of 16:17, 11 September 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Other Diagnostic Studies

One diagnostic test used in the past for a pheochromocytoma is to administer clonidine, a centrally-acting alpha-2 agonist used to treat high blood pressure. Clonidine mimics catecholamines in the brain, causing it to reduce the activity of the sympathetic nerves controlling the adrenal medulla. A healthy adrenal medulla will respond to the Clonidine suppression test by reducing catecholamine production; the lack of a response is evidence of pheochromocytoma.

References

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