Primary central nervous system lymphoma MRI: Difference between revisions

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{{Primary central nervous system lymphoma}}
{{Primary central nervous system lymphoma}}
==Overview==
==Overview==
'''Primary CNS lymphoma''' is a [[brain tumor|primary intracranial tumor]] usually present in those with severe immunosuppression --- commonly in those with [[AIDS]] --- and represents around 20% of all cases of lymphomas in HIV infection (other types being [[Burkitt's lymphoma]] and immunoblastic lymphoma). Primary CNS lymphoma (PCNSL) is highly associated with [[Epstein-Barr virus]] infection (> 90%) in immunodeficient patients<ref>Fine HA, Mayer RJ. Primary central nervous system lymphoma. ''Ann Intern Med'' 1993; 119(11):1093-1104</ref> (such as those with AIDS and those iatrogenically immunosupressed) and does not have predilections for any age group. Mean [[CD4]]+ count at time of diagnosis is ~50/uL. Because of the severity of immunosuppression at the time of diagnosis, it is to no surprise that prognosis is usually poor.  In immunocompetent patients (that is, patients that do not have AIDS or some other immunodeficiency) there is rarely an association with EBV infection or other infectious DNAs.  In the immunocompetent population, PCNSL typically affects older patients in their 50's and 60's.
'''Primary CNS lymphoma''' is a [[brain tumor|primary intracranial tumor]] usually present in those with severe immunosuppression --- commonly in those with [[AIDS]] --- and represents around 20% of all cases of lymphomas in HIV infection (other types being [[Burkitt's lymphoma]] and immunoblastic lymphoma).
==MRI==
[[MRI]] or contrast enhanced [[CT]] usually shows multiple (1 to 3) 3- to 5-cm ring-enhancing lesions in almost any location, but usually deep in the white matter. The major [[differential diagnosis]] is cerebral [[toxoplasmosis]], which is also prevalent in AIDS patients and also presents with a ring-enhanced lesion, although the contrast enhancement is more pronounced in toxoplasmosis and it presents with more lesions.
 
==MRI==
==MRI==
==References==
==References==

Revision as of 18:49, 21 January 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Primary CNS lymphoma is a primary intracranial tumor usually present in those with severe immunosuppression --- commonly in those with AIDS --- and represents around 20% of all cases of lymphomas in HIV infection (other types being Burkitt's lymphoma and immunoblastic lymphoma).

MRI

MRI or contrast enhanced CT usually shows multiple (1 to 3) 3- to 5-cm ring-enhancing lesions in almost any location, but usually deep in the white matter. The major differential diagnosis is cerebral toxoplasmosis, which is also prevalent in AIDS patients and also presents with a ring-enhanced lesion, although the contrast enhancement is more pronounced in toxoplasmosis and it presents with more lesions.

MRI

References


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