Hepatosplenic T cell lymphoma pathophysiology: Difference between revisions
(Created page with "{{Hepatosplenic T cell lymphoma}} {{CMG}} ==Overview== ==References== {{reflist|2}} Category:Disease Category:Types of cancer Category:Oncology [[Category:Gast...") |
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==Overview== | ==Overview== | ||
==Sites of Involvement=== | |||
The [[spleen]] and [[liver]] are always involved, with [[bone marrow]] involvement frequently present. Nodal involvement is exceedingly rare.[http://www.iarc.fr/WHO-BlueBooks/BBwebsite/bb3.html] Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): '''World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haemopoietic and Lymphoid Tissues.''' IARC Press: Lyon 2001 </ref> | |||
==Morphology== | |||
The neoplastic cells in this disorder show a monotonous appearance, with a small amount of [[cytoplasm]] and inconspicuous [[nucleoli]]. | |||
===Spleen and liver=== | |||
This disease shows a distinct [[sinusoidal]] pattern of infiltration which spares the splenic [[white pulp]] and hepatic [[portal triads]]. | |||
===Bone marrow=== | |||
While the [[bone marrow]] is commonly involved, the detection of the neoplastic infiltrate may be difficult due to diffuse, interstitial pattern. [[Immunohistochemistry]] can aid in the detection of this [[lymphoma]]. | |||
===Peripheral blood=== | |||
Cells of a similar morphology observed in solid organs are observed in peripheral [[blood]]. | |||
==References== | ==References== | ||
Revision as of 19:40, 21 January 2012
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Hepatosplenic T cell lymphoma Microchapters |
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Differentiating Hepatosplenic T cell lymphoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Sites of Involvement=
The spleen and liver are always involved, with bone marrow involvement frequently present. Nodal involvement is exceedingly rare.[2] Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haemopoietic and Lymphoid Tissues. IARC Press: Lyon 2001 </ref>
Morphology
The neoplastic cells in this disorder show a monotonous appearance, with a small amount of cytoplasm and inconspicuous nucleoli.
Spleen and liver
This disease shows a distinct sinusoidal pattern of infiltration which spares the splenic white pulp and hepatic portal triads.
Bone marrow
While the bone marrow is commonly involved, the detection of the neoplastic infiltrate may be difficult due to diffuse, interstitial pattern. Immunohistochemistry can aid in the detection of this lymphoma.
Peripheral blood
Cells of a similar morphology observed in solid organs are observed in peripheral blood.
References