Myelodysplastic syndrome other diagnostic studies: Difference between revisions
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{{Myelodysplastic syndrome}} | {{Myelodysplastic syndrome}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
==Other Diagnostic Studies== | |||
==Bone marrow biopsy== | ===Bone marrow biopsy=== | ||
[[Bone marrow examination]] by an experienced [[hematopathologist]]. This is required to establish the diagnosis, since all hematopathologists recognize a dysplastic marrow as the key feature of myelodysplasia. | [[Bone marrow examination]] by an experienced [[hematopathologist]]. This is required to establish the diagnosis, since all hematopathologists recognize a dysplastic marrow as the key feature of myelodysplasia. | ||
==Cytogenetics== | ===Cytogenetics=== | ||
[[Cytogenetics]] or chromosomal studies. This is ideally performed on the bone marrow aspirate. These require a fresh specimen, since live cells are induced to enter [[metaphase]] to enhance [[chromosomal]] staining. | [[Cytogenetics]] or chromosomal studies. This is ideally performed on the bone marrow aspirate. These require a fresh specimen, since live cells are induced to enter [[metaphase]] to enhance [[chromosomal]] staining. | ||
==Flow cytometry== | ===Flow cytometry=== | ||
[[Flow cytometry]] is helpful to establish the presence of any [[lymphoproliferative]] disorder in the [[marrow]] | [[Flow cytometry]] is helpful to establish the presence of any [[lymphoproliferative]] disorder in the [[marrow]] | ||
Revision as of 16:54, 11 September 2012
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Differentiating Myelodysplastic syndrome from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Other Diagnostic Studies
Bone marrow biopsy
Bone marrow examination by an experienced hematopathologist. This is required to establish the diagnosis, since all hematopathologists recognize a dysplastic marrow as the key feature of myelodysplasia.
Cytogenetics
Cytogenetics or chromosomal studies. This is ideally performed on the bone marrow aspirate. These require a fresh specimen, since live cells are induced to enter metaphase to enhance chromosomal staining.
Flow cytometry
Flow cytometry is helpful to establish the presence of any lymphoproliferative disorder in the marrow